Force transmission in migrating cells

During cell migration, forces generated by the actin cytoskeleton are transmitted through adhesion complexes to the substrate. To investigate the mechanism of force generation and transmission, we analyzed the relationship between actin network velocity and traction forces at the substrate in a mode...

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Veröffentlicht in:	The Journal of cell biology 2010-01, Vol.188 (2), p.287-297
Hauptverfasser:	Fournier, Maxime F, Sauser, Roger, Ambrosi, Davide, Meister, Jean-Jacques, Verkhovsky, Alexander B
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Cytoskeleton - drug effects Actin Cytoskeleton - physiology Actin Cytoskeleton - ultrastructure Actins Analysis Animal migration behavior Animals Biomechanical Phenomena - physiology Cell adhesion & migration Cell Adhesion - drug effects Cell Adhesion - physiology Cell Movement - drug effects Cell Movement - physiology Cell Polarity - physiology Cell Shape - drug effects Cell Shape - physiology Cells Cells, Cultured Coupling coefficients Critical velocity Cytochalasin D - pharmacology Cytochalasins Cytoskeleton Cytoskeleton - physiology Cytoskeleton - ultrastructure Deformation Fish Fishes Gelatins Heterocyclic Compounds, 4 or More Rings - pharmacology Keratinocytes - physiology Keratinocytes - ultrastructure Kinetics Models, Biological Myosins - drug effects Myosins - physiology Myosins - ultrastructure Protein Synthesis Inhibitors - pharmacology Stress, Mechanical Tensile Strength - physiology Velocity
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