Prostaglandin E2 induces fibroblast apoptosis by modulating multiple survival pathways

ABSTRACT Although the lipid mediator prostaglandin E2 (PGE2) exerts antifibrotic effects by inhibiting multiple fibroblast functions, its ability to regulate fibroblast survival is unknown. Here, we examined the effects of this prostanoid on apoptosis and apoptosis pathways in normal and fibrotic lu...

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Veröffentlicht in:	The FASEB journal 2009-12, Vol.23 (12), p.4317-4326
Hauptverfasser:	Huang, Steven K., White, Eric S., Wettlaufer, Scott H., Grifka, Heather, Hogaboam, Cory M., Thannickal, Victor J., Horowitz, Jeffrey C., Peters-Golden, Marc
Format:	Artikel
Sprache:	eng
Schlagworte:	Akt Fas idiopathic pulmonary fibrosis PTEN Research Communications survivin
Online-Zugang:	Volltext
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