Phosphoglycerate kinase 1 a promoting enzyme for peritoneal dissemination in gastric cancer

Peritoneal carcinomatosis is a frequent finding in gastric cancer associated with a poor prognosis. The features that enable gastric tumors to disseminate are poorly understood until now. Previously, we showed elevated mRNA levels of phosphoglycerate kinase 1 (PGK1), an adenosine triphosphate‐genera...

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Veröffentlicht in:	International journal of cancer 2010-03, Vol.126 (6), p.1513-1520
Hauptverfasser:	Zieker, Derek, Königsrainer, Ingmar, Tritschler, Isabel, Löffler, Markus, Beckert, Stefan, Traub, Frank, Nieselt, Kay, Bühler, Sarah, Weller, Michael, Gaedcke, Jochen, Taichman, Russell S., Northoff, Hinnak, Brücher, Björn L.D.M., Königsrainer, Alfred
Format:	Artikel
Sprache:	eng
Schlagworte:	Abdomen beta Catenin - genetics beta Catenin - metabolism Biological and medical sciences Blotting, Western cancer dissemination Cell Line, Tumor Cell Movement - genetics Cell Movement - physiology Cell Survival - genetics Cell Survival - physiology CXCL12 CXCR4 gastric cancer Gastroenterology. Liver. Pancreas. Abdomen Gene Expression Regulation, Neoplastic Humans Immunohistochemistry Medical sciences Models, Biological peritoneal carcinomatosis Peritoneal Neoplasms - genetics Peritoneal Neoplasms - metabolism Peritoneal Neoplasms - secondary PGK1 Phosphoglycerate Kinase - genetics Phosphoglycerate Kinase - metabolism Receptors, CXCR4 - genetics Receptors, CXCR4 - metabolism Reverse Transcriptase Polymerase Chain Reaction RNA Interference Signal Transduction - genetics Signal Transduction - physiology Stomach Neoplasms - genetics Stomach Neoplasms - metabolism Stomach Neoplasms - pathology Tumors
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