Efficient Synthesis of B-Alkylated Oxazaborolidines Derived from Ephedrine and Norephedrine
Representative B-butyl- and B-methyl-1,3,2-oxazaborolidines derived from ephedrine and norephedrine were prepared in good yield and excellent purity by one-pot treatment of B-H oxazaborolidines with the corresponding organolithium reagent and subsequent hydrolysis of the cyclic borohydride intermedi...
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| Veröffentlicht in: | Organic letters 2003-09, Vol.5 (19), p.3447-3449 |
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| container_title | Organic letters |
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| creator | Ortiz-Marciales, Margarita González, Eduvigis De Jesús, Melvin Espinosa, Sandraliz Correa, Wildeliz Martínez, Johanna Figueroa, Ruth |
| description | Representative B-butyl- and B-methyl-1,3,2-oxazaborolidines derived from ephedrine and norephedrine were prepared in good yield and excellent purity by one-pot treatment of B-H oxazaborolidines with the corresponding organolithium reagent and subsequent hydrolysis of the cyclic borohydride intermediate with anhydrous ammonium chloride. |
| doi_str_mv | 10.1021/ol0352153 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 1523-7060 |
| ispartof | Organic letters, 2003-09, Vol.5 (19), p.3447-3449 |
| issn | 1523-7060 1523-7052 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2811074 |
| source | MEDLINE; ACS Publications |
| subjects | Alkylation Borohydrides - chemistry Boron Compounds - chemical synthesis Ephedrine - analogs & derivatives Lithium Compounds - chemistry Molecular Structure Oxazines - chemical synthesis Phenylpropanolamine - analogs & derivatives Stereoisomerism |
| title | Efficient Synthesis of B-Alkylated Oxazaborolidines Derived from Ephedrine and Norephedrine |
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