The potential of Latent Class Analysis in diagnostic test validation for canine Leishmania infantum infection
Accuracy assessment of diagnostic tests may be seriously biased if an imperfect reference test is used such as parasitology in the diagnosis of visceral leishmaniasis. We compared classical validity analysis of serological tests for Leishmania infantum with Latent Class Analysis (LCA), to assess whe...
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| Veröffentlicht in: | Epidemiology and infection 1999-12, Vol.123 (3), p.499-506 |
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| creator | BOELAERT, M. AOUN, K. LIINEV, J. GOETGHEBEUR, E. VAN DER STUYFT, P. |
| description | Accuracy assessment of diagnostic tests may be seriously biased if an imperfect reference test is
used such as parasitology in the diagnosis of visceral leishmaniasis. We compared classical
validity analysis of serological tests for Leishmania infantum with Latent Class Analysis (LCA),
to assess whether it circumvented the gold standard problem. Clinical status, three serological
tests (IFAT, ELISA and DAT) and parasitological data were recorded for 151 dogs captured
in an endemic area. Sensitivity and specificity estimates from the 2×2 contingency tables were
broadly corroborated by LCA, but the latter method provided more precise estimates that were
robust for the different fitted models. It furthermore yielded a higher prevalence of infection
and indicated that parasitology was only 55% sensitive. LCA seems a promising technique for
test validation, but caution is required when applying it to sparse data sets. The feasibility and
applicability of LCA in infectious disease epidemiology is discussed. |
| doi_str_mv | 10.1017/S0950268899003040 |
| format | Article |
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used such as parasitology in the diagnosis of visceral leishmaniasis. We compared classical
validity analysis of serological tests for Leishmania infantum with Latent Class Analysis (LCA),
to assess whether it circumvented the gold standard problem. Clinical status, three serological
tests (IFAT, ELISA and DAT) and parasitological data were recorded for 151 dogs captured
in an endemic area. Sensitivity and specificity estimates from the 2×2 contingency tables were
broadly corroborated by LCA, but the latter method provided more precise estimates that were
robust for the different fitted models. It furthermore yielded a higher prevalence of infection
and indicated that parasitology was only 55% sensitive. LCA seems a promising technique for
test validation, but caution is required when applying it to sparse data sets. The feasibility and
applicability of LCA in infectious disease epidemiology is discussed.</description><identifier>ISSN: 0950-2688</identifier><identifier>EISSN: 1469-4409</identifier><identifier>DOI: 10.1017/S0950268899003040</identifier><identifier>PMID: 10694163</identifier><identifier>CODEN: EPINEU</identifier><language>eng</language><publisher>Cambridge: Cambridge University Press</publisher><subject>Animal protozoal diseases ; Animals ; Biological and medical sciences ; Canines ; Disease models ; Dog Diseases - diagnosis ; Dog Diseases - epidemiology ; Dog Diseases - parasitology ; Dogs ; Epidemiology ; Infections ; Infectious diseases ; Leishmania infantum ; Leishmania infantum - pathogenicity ; Leishmaniasis, Visceral - diagnosis ; Leishmaniasis, Visceral - epidemiology ; Leishmaniasis, Visceral - veterinary ; Life Sciences ; Medical diagnostic tests ; Medical sciences ; Microbiology and Parasitology ; Parametric models ; Parasitic diseases ; Parasitology ; Predictive Value of Tests ; Prevalence ; Protozoal diseases ; Reference Values ; Santé publique et épidémiologie ; Sensitivity and Specificity ; Serologic Tests ; Visceral leishmaniasis</subject><ispartof>Epidemiology and infection, 1999-12, Vol.123 (3), p.499-506</ispartof><rights>1999 Cambridge University Press</rights><rights>Copyright 1999 Cambridge University Press</rights><rights>2000 INIST-CNRS</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c596t-9750c8c7dcf42d9efbeb23d561579732388ffcc7be39945aa1cb97a04505375e3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/4617501$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/4617501$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,723,776,780,799,881,27901,27902,53766,53768,57992,58225</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1262324$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10694163$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://riip.hal.science/pasteur-02043583$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>BOELAERT, M.</creatorcontrib><creatorcontrib>AOUN, K.</creatorcontrib><creatorcontrib>LIINEV, J.</creatorcontrib><creatorcontrib>GOETGHEBEUR, E.</creatorcontrib><creatorcontrib>VAN DER STUYFT, P.</creatorcontrib><title>The potential of Latent Class Analysis in diagnostic test validation for canine Leishmania infantum infection</title><title>Epidemiology and infection</title><addtitle>Epidemiol. Infect</addtitle><description>Accuracy assessment of diagnostic tests may be seriously biased if an imperfect reference test is
used such as parasitology in the diagnosis of visceral leishmaniasis. We compared classical
validity analysis of serological tests for Leishmania infantum with Latent Class Analysis (LCA),
to assess whether it circumvented the gold standard problem. Clinical status, three serological
tests (IFAT, ELISA and DAT) and parasitological data were recorded for 151 dogs captured
in an endemic area. Sensitivity and specificity estimates from the 2×2 contingency tables were
broadly corroborated by LCA, but the latter method provided more precise estimates that were
robust for the different fitted models. It furthermore yielded a higher prevalence of infection
and indicated that parasitology was only 55% sensitive. LCA seems a promising technique for
test validation, but caution is required when applying it to sparse data sets. The feasibility and
applicability of LCA in infectious disease epidemiology is discussed.</description><subject>Animal protozoal diseases</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Canines</subject><subject>Disease models</subject><subject>Dog Diseases - diagnosis</subject><subject>Dog Diseases - epidemiology</subject><subject>Dog Diseases - parasitology</subject><subject>Dogs</subject><subject>Epidemiology</subject><subject>Infections</subject><subject>Infectious diseases</subject><subject>Leishmania infantum</subject><subject>Leishmania infantum - pathogenicity</subject><subject>Leishmaniasis, Visceral - diagnosis</subject><subject>Leishmaniasis, Visceral - epidemiology</subject><subject>Leishmaniasis, Visceral - veterinary</subject><subject>Life Sciences</subject><subject>Medical diagnostic tests</subject><subject>Medical sciences</subject><subject>Microbiology and Parasitology</subject><subject>Parametric models</subject><subject>Parasitic diseases</subject><subject>Parasitology</subject><subject>Predictive Value of Tests</subject><subject>Prevalence</subject><subject>Protozoal diseases</subject><subject>Reference Values</subject><subject>Santé publique et épidémiologie</subject><subject>Sensitivity and Specificity</subject><subject>Serologic Tests</subject><subject>Visceral leishmaniasis</subject><issn>0950-2688</issn><issn>1469-4409</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkk2P0zAQhiMEYsvCD0BCyAfELeCv2PEFqapgi1SBKsqFizVxnNYliYudVOy_x1Gr7gISnDzW-8x45h1n2XOC3xBM5NsvWBWYirJUCmOGOX6QzQgXKuccq4fZbJLzSb_KnsS4xxgrWsrH2RXBQnEi2CzrNjuLDn6w_eCgRb5BK5guaNFCjGjeQ3sbXUSuR7WDbe_j4AwabBzQEVpXw-B8jxofkIHe9RatrIu7LsWQchroh7GbAmsm8Gn2qIE22mfn8zr7-uH9ZrHMV59vPi7mq9wUSgy5kgU2pZG1aTitlW0qW1FWF4IUUklGWVk2jTGyskwpXgAQUykJmBe4YLKw7Dp7d6p7GKvO1iYNFKDVh-A6CLfag9O_K73b6a0_aloSLEuRCuSnArs_0pbzlT5AHOwYNKaYs6JkR5L41-cHg_8xJnd056KxbQu99WPUyW6mBBf_BYks0tIITSA5gSb4GINtLm0QrKft67-2n3Je3h_7XsZp3Ql4dQYgGmibAL1x8Y6jgjLKE_bihO3j4MNF5iJ1h8mdOS758PMiQ_iuhUz-a3Gz1ph8-rZc07XeJJ6dR4GuCq7eWr33Y0hfK_5jmF9S2uCB</recordid><startdate>19991201</startdate><enddate>19991201</enddate><creator>BOELAERT, M.</creator><creator>AOUN, K.</creator><creator>LIINEV, J.</creator><creator>GOETGHEBEUR, E.</creator><creator>VAN DER STUYFT, P.</creator><general>Cambridge University Press</general><general>Cambridge University Press (CUP)</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>M7N</scope><scope>7X8</scope><scope>1XC</scope><scope>5PM</scope></search><sort><creationdate>19991201</creationdate><title>The potential of Latent Class Analysis in diagnostic test validation for canine Leishmania infantum infection</title><author>BOELAERT, M. ; AOUN, K. ; LIINEV, J. ; GOETGHEBEUR, E. ; VAN DER STUYFT, P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c596t-9750c8c7dcf42d9efbeb23d561579732388ffcc7be39945aa1cb97a04505375e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Animal protozoal diseases</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Canines</topic><topic>Disease models</topic><topic>Dog Diseases - diagnosis</topic><topic>Dog Diseases - epidemiology</topic><topic>Dog Diseases - parasitology</topic><topic>Dogs</topic><topic>Epidemiology</topic><topic>Infections</topic><topic>Infectious diseases</topic><topic>Leishmania infantum</topic><topic>Leishmania infantum - pathogenicity</topic><topic>Leishmaniasis, Visceral - diagnosis</topic><topic>Leishmaniasis, Visceral - epidemiology</topic><topic>Leishmaniasis, Visceral - veterinary</topic><topic>Life Sciences</topic><topic>Medical diagnostic tests</topic><topic>Medical sciences</topic><topic>Microbiology and Parasitology</topic><topic>Parametric models</topic><topic>Parasitic diseases</topic><topic>Parasitology</topic><topic>Predictive Value of Tests</topic><topic>Prevalence</topic><topic>Protozoal diseases</topic><topic>Reference Values</topic><topic>Santé publique et épidémiologie</topic><topic>Sensitivity and Specificity</topic><topic>Serologic Tests</topic><topic>Visceral leishmaniasis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>BOELAERT, M.</creatorcontrib><creatorcontrib>AOUN, K.</creatorcontrib><creatorcontrib>LIINEV, J.</creatorcontrib><creatorcontrib>GOETGHEBEUR, E.</creatorcontrib><creatorcontrib>VAN DER STUYFT, P.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Epidemiology and infection</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>BOELAERT, M.</au><au>AOUN, K.</au><au>LIINEV, J.</au><au>GOETGHEBEUR, E.</au><au>VAN DER STUYFT, P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The potential of Latent Class Analysis in diagnostic test validation for canine Leishmania infantum infection</atitle><jtitle>Epidemiology and infection</jtitle><addtitle>Epidemiol. Infect</addtitle><date>1999-12-01</date><risdate>1999</risdate><volume>123</volume><issue>3</issue><spage>499</spage><epage>506</epage><pages>499-506</pages><issn>0950-2688</issn><eissn>1469-4409</eissn><coden>EPINEU</coden><abstract>Accuracy assessment of diagnostic tests may be seriously biased if an imperfect reference test is
used such as parasitology in the diagnosis of visceral leishmaniasis. We compared classical
validity analysis of serological tests for Leishmania infantum with Latent Class Analysis (LCA),
to assess whether it circumvented the gold standard problem. Clinical status, three serological
tests (IFAT, ELISA and DAT) and parasitological data were recorded for 151 dogs captured
in an endemic area. Sensitivity and specificity estimates from the 2×2 contingency tables were
broadly corroborated by LCA, but the latter method provided more precise estimates that were
robust for the different fitted models. It furthermore yielded a higher prevalence of infection
and indicated that parasitology was only 55% sensitive. LCA seems a promising technique for
test validation, but caution is required when applying it to sparse data sets. The feasibility and
applicability of LCA in infectious disease epidemiology is discussed.</abstract><cop>Cambridge</cop><pub>Cambridge University Press</pub><pmid>10694163</pmid><doi>10.1017/S0950268899003040</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Epidemiology and infection, 1999-12, Vol.123 (3), p.499-506 |
| issn | 0950-2688 1469-4409 |
| language | eng |
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| source | Jstor Complete Legacy; MEDLINE; PubMed Central |
| subjects | Animal protozoal diseases Animals Biological and medical sciences Canines Disease models Dog Diseases - diagnosis Dog Diseases - epidemiology Dog Diseases - parasitology Dogs Epidemiology Infections Infectious diseases Leishmania infantum Leishmania infantum - pathogenicity Leishmaniasis, Visceral - diagnosis Leishmaniasis, Visceral - epidemiology Leishmaniasis, Visceral - veterinary Life Sciences Medical diagnostic tests Medical sciences Microbiology and Parasitology Parametric models Parasitic diseases Parasitology Predictive Value of Tests Prevalence Protozoal diseases Reference Values Santé publique et épidémiologie Sensitivity and Specificity Serologic Tests Visceral leishmaniasis |
| title | The potential of Latent Class Analysis in diagnostic test validation for canine Leishmania infantum infection |
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