Beneficial Immunomodulation by Streptococcus mutans Anti-P1 Monoclonal Antibodies Is Fc Independent and Correlates with Increased Exposure of a Relevant Target Epitope

We showed previously that deliberate immunization of BALB/c mice with immune complexes (IC) of the cariogenic bacterium Streptococcus mutans and mAbs against its surface adhesin P1 results in changes in the specificity and isotype of elicited anti-P1 Abs. Depending on the mAb, changes were beneficia...

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Veröffentlicht in:	The Journal of immunology (1950) 2009-10, Vol.183 (7), p.4628-4638
Hauptverfasser:	Robinette, Rebekah A, Oli, Monika W, McArthur, William P, Brady, L. Jeannine
Format:	Artikel
Sprache:	eng
Schlagworte:	Adhesins, Bacterial - administration & dosage Adhesins, Bacterial - genetics Adhesins, Bacterial - immunology Agglutinins - immunology Agglutinins - metabolism Animals Antibodies, Monoclonal - blood Antibodies, Monoclonal - therapeutic use Bacterial Adhesion - genetics Bacterial Adhesion - immunology Binding Sites, Antibody Epitopes - administration & dosage Epitopes - genetics Epitopes - immunology Female Genetic Predisposition to Disease Humans Immunoglobulin Fc Fragments - physiology Male Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Transgenic Salivary Proteins and Peptides - immunology Salivary Proteins and Peptides - metabolism Streptococcus mutans - genetics Streptococcus mutans - immunology
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