Studying rod photoreceptor development in zebrafish
The zebrafish has rapidly become a favored model vertebrate organism, well suited for studies of developmental processes using large-scale genetic screens. In particular, zebrafish morphological and behavioral genetic screens have led to the identification of genes important for development of the r...
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| Veröffentlicht in: | Physiology & behavior 2005-10, Vol.86 (3), p.306-313 |
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| creator | Morris, A.C. Fadool, J.M. |
| description | The zebrafish has rapidly become a favored model vertebrate organism, well suited for studies of developmental processes using large-scale genetic screens. In particular, zebrafish morphological and behavioral genetic screens have led to the identification of genes important for development of the retinal photoreceptors. This may help clarify the genetic mechanisms underlying human photoreceptor development and dysfunction in retinal diseases. In this review, we present the advantages of zebrafish as a vertebrate model organism, summarize retinal and photoreceptor cell development in zebrafish, with emphasis on the rod photoreceptors, and describe zebrafish visual behaviors that can be used for genetic screens. We then describe some of the photoreceptor cell mutants that have been isolated in morphological and behavioral screens and discuss the limitations of current screening methods for uncovering mutations that specifically affect rod function. Finally, we present some alternative strategies to target the rod developmental pathway in zebrafish. |
| doi_str_mv | 10.1016/j.physbeh.2005.08.020 |
| format | Article |
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Psychology</subject><subject>Genetics</subject><subject>Models, Animal</subject><subject>Retinal development</subject><subject>Retinal Rod Photoreceptor Cells - growth & development</subject><subject>Vertebrates: nervous system and sense organs</subject><subject>Zebrafish</subject><subject>Zebrafish - physiology</subject><issn>0031-9384</issn><issn>1873-507X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1v1DAQhi1ERZfCTwDlArekYzuxnQuoqviSKnEAJG6WY08ar7JxsLMrLb--LhtRONUHz8HPzLx6TMgrChUFKi631TwcU4dDxQCaClQFDJ6QDVWSlw3In0_JBoDTsuWqPifPU9pCPrzmz8g5FbRtQagN4d-WvTv66baIwRXzEJYQ0eKcS-HwgGOYdzgthZ-K39hF0_s0vCBnvRkTvlzrBfnx8cP368_lzddPX66vbkpbt81SCqxZTUVrwArp2nwz1zQSZe2cAsSukYzJzoJDITuHvOvrzinacSccouAX5N1p7rzvduhszhHNqOfodyYedTBe__8y-UHfhoNmKisCmge8XQfE8GuPadE7nyyOo5kw7JMWSjIOvMlgcwJtDClF7P8uoaDvdeutXnXre90alM66c9_rfxM-dK1-M_BmBUyyZuyjmaxPD5xkteR_kr4_cZh9HjxGnazHyaLz-TsW7YJ_JModPOGi7Q</recordid><startdate>20051015</startdate><enddate>20051015</enddate><creator>Morris, A.C.</creator><creator>Fadool, J.M.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20051015</creationdate><title>Studying rod photoreceptor development in zebrafish</title><author>Morris, A.C. ; Fadool, J.M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c495t-6e424169a0c67d90c62d557e74dd80eeb57227bc0de67bde3bf4bd81b3d6dee63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Animals</topic><topic>Animals, Genetically Modified</topic><topic>Behavior, Animal - physiology</topic><topic>Biological and medical sciences</topic><topic>Eye and associated structures. Visual pathways and centers. Vision</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Genetics</topic><topic>Models, Animal</topic><topic>Retinal development</topic><topic>Retinal Rod Photoreceptor Cells - growth & development</topic><topic>Vertebrates: nervous system and sense organs</topic><topic>Zebrafish</topic><topic>Zebrafish - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Morris, A.C.</creatorcontrib><creatorcontrib>Fadool, J.M.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Physiology & behavior</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Morris, A.C.</au><au>Fadool, J.M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Studying rod photoreceptor development in zebrafish</atitle><jtitle>Physiology & behavior</jtitle><addtitle>Physiol Behav</addtitle><date>2005-10-15</date><risdate>2005</risdate><volume>86</volume><issue>3</issue><spage>306</spage><epage>313</epage><pages>306-313</pages><issn>0031-9384</issn><eissn>1873-507X</eissn><abstract>The zebrafish has rapidly become a favored model vertebrate organism, well suited for studies of developmental processes using large-scale genetic screens. 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| identifier | ISSN: 0031-9384 |
| ispartof | Physiology & behavior, 2005-10, Vol.86 (3), p.306-313 |
| issn | 0031-9384 1873-507X |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2810101 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals Animals, Genetically Modified Behavior, Animal - physiology Biological and medical sciences Eye and associated structures. Visual pathways and centers. Vision Fundamental and applied biological sciences. Psychology Genetics Models, Animal Retinal development Retinal Rod Photoreceptor Cells - growth & development Vertebrates: nervous system and sense organs Zebrafish Zebrafish - physiology |
| title | Studying rod photoreceptor development in zebrafish |
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