Synthesis and antimicrobial activity of 5-imidazolinone derivatives

Synthesis and antimicrobial activity of 5-imidazolinone derivatives

Several 4-arylidene-2-phenyl-1-(2,4,5-trichlorophenyl)-1H-imidazol-5(4H)-ones (4a-q), N-(4-benzylidene-5-oxo-2-phenyl-4,5-dihydroimidazol-1-yl)-4-chlorobenzamides (5a-o) and N-(4-benzylidene-5-oxo-2-phenyl-4,5-dihydroimidazol-1-yl)-2,4-dichlorobenzamides (6a-m) were prepared. All newly synthesized c...

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Veröffentlicht in:Indian journal of pharmaceutical sciences 2009-01, Vol.71 (1), p.90-94
Hauptverfasser: Desai, N C, Bhavsar, A M, Baldaniya, B B
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Sprache:eng
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Bacteria
Pharmaceutical chemistry
Pharmaceutical microbiology
Short Communication
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container_title Indian journal of pharmaceutical sciences
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creator Desai, N C
Bhavsar, A M
Baldaniya, B B
description Several 4-arylidene-2-phenyl-1-(2,4,5-trichlorophenyl)-1H-imidazol-5(4H)-ones (4a-q), N-(4-benzylidene-5-oxo-2-phenyl-4,5-dihydroimidazol-1-yl)-4-chlorobenzamides (5a-o) and N-(4-benzylidene-5-oxo-2-phenyl-4,5-dihydroimidazol-1-yl)-2,4-dichlorobenzamides (6a-m) were prepared. All newly synthesized compounds have been tested for their antibacterial activity against gram (+)ve and gram (-)ve bacteria and also on different strains of fungi. Introduction of OH, OCH(3), NO(2), Cl and Br groups to the heterocyclic frame work enhanced antibacterial and antifungal activities.
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source Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; PubMed Central Open Access
subjects Bacteria
Pharmaceutical chemistry
Pharmaceutical microbiology
Short Communication
title Synthesis and antimicrobial activity of 5-imidazolinone derivatives
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