Inadequacy of Plasma Acyclovir Levels at Delivery in Patients With Genital Herpes Receiving Oral Acyclovir Suppressive Therapy in Late Pregnancy

Abstract Objective Acyclovir therapy in late pregnancy among women with recurrent genital herpes is effective in decreasing genital lesion frequency and subclinical viral shedding rates at delivery, thereby decreasing the need for Caesarean section. Despite good adherence and increased dosing schedu...

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Veröffentlicht in:	Journal of obstetrics and gynaecology Canada 2009-12, Vol.31 (12), p.1137-1143
Hauptverfasser:	Leung, Daniel T., MD, MSc, Henning, Paul A., MD, Wagner, Emily C., MSc, Blasig, Audrey, MD, MHSc, Wald, Anna, MD, Sacks, Stephen L., MD, FRCPC, Corey, Lawrence, MD, Money, Deborah M., MD, FRCSC
Format:	Artikel
Sprache:	eng
Schlagworte:	Acyclovir - administration & dosage Acyclovir - blood Administration, Oral Adult Antiviral Agents - administration & dosage Antiviral Agents - blood Cohort Studies Delivery, Obstetric Dose-Response Relationship, Drug Female Fetal Blood - chemistry Herpes Genitalis - drug therapy Herpes Genitalis - prevention & control Herpes Genitalis - transmission Humans Infant, Newborn Infectious Disease Transmission, Vertical - prevention & control Labor, Obstetric Obstetrics and Gynecology Pregnancy Pregnancy Complications, Infectious - drug therapy Recurrence Simplexvirus Treatment Outcome Virus Shedding
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