Octamer binding protein 2 (Oct2) regulates PD-L2 gene expression in B-1 cells through lineage-specific activity of a unique, intronic promoter

Programmed death-1 ligand 2 (PD-L2) expression extends beyond macrophages/dendritic cells to B-1 B cells, a distinct B-cell lineage that is responsible for natural immunoglobulin and which is repertoire skewed toward autoreactive specificities. PD-L2 expression is constitutive in B-1 cells, whereas...

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Veröffentlicht in:	Genes and immunity 2010-01, Vol.11 (1), p.55-66
Hauptverfasser:	Kaku, H, Rothstein, T L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies Antigens Apoptosis B cells B-1 cells B-Lymphocytes - metabolism Biomedical and Life Sciences Biomedicine Cancer Research Cell Line, Tumor Cell lineage Chemical properties Dendritic cells DNA binding proteins Exons Gene Expression Gene Expression Regulation - physiology Genetic aspects Human Genetics Immunoglobulins Immunology L2 gene Ligands Lupus Lymphocytes Lymphocytes B Macrophages Macrophages, Peritoneal - metabolism Medical research Mice Mice, Inbred BALB C Oct-2 protein Octamer Transcription Factor-1 - genetics Octamer Transcription Factor-1 - metabolism Octamer Transcription Factor-2 - genetics Octamer Transcription Factor-2 - metabolism Oncology Organ Specificity - physiology original-article PD-L1 protein Peptides - metabolism Physiological aspects Polymorphism Programmed Cell Death 1 Ligand 2 Protein Promoter Regions, Genetic - physiology Promoters Promoters (Genetics) Proteins Transcription Transcription factors Transcription, Genetic - physiology
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