Flux Design: In silico design of cell factories based on correlation of pathway fluxes to desired properties

The identification of genetic target genes is a key step for rational engineering of production strains towards bio-based chemicals, fuels or therapeutics. This is often a difficult task, because superior production performance typically requires a combination of multiple targets, whereby the comple...

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Veröffentlicht in:	BMC systems biology 2009-12, Vol.3 (1), p.120-120, Article 120
Hauptverfasser:	Melzer, Guido, Esfandabadi, Manely Eslahpazir, Franco-Lara, Ezequiel, Wittmann, Christoph
Format:	Artikel
Sprache:	eng
Schlagworte:	Aspergillus niger Aspergillus niger - cytology Aspergillus niger - enzymology Aspergillus niger - genetics Aspergillus niger - metabolism Biocatalysis Biotechnology Biotechnology - methods Cellular control mechanisms Computational Biology - methods Corynebacterium glutamicum Corynebacterium glutamicum - cytology Corynebacterium glutamicum - genetics Corynebacterium glutamicum - metabolism Epoxide Hydrolases - metabolism Epoxy Compounds - chemistry Epoxy Compounds - metabolism Gene Deletion Glucan 1,4-alpha-Glucosidase - metabolism Glucose - metabolism Kinetics Lysine - biosynthesis Lysine - metabolism Metabolic engineering Metabolic Networks and Pathways Nucleic Acid Amplification Techniques Oligosaccharides - biosynthesis Research article Starch - metabolism Stereoisomerism Systems Biology - methods
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