Distinct effects of CGRP on typical and atypical smooth muscle cells involved in generating spontaneous contractions in the mouse renal pelvis

Background and purpose: We investigated the cellular mechanisms underlying spontaneous contractions in the mouse renal pelvis, regulated by calcitonin gene‐related peptide (CGRP). Experimental approach: Spontaneous contractions, action potentials and Ca2+ transients in typical and atypical smooth...

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Veröffentlicht in:	British journal of pharmacology 2009-12, Vol.158 (8), p.2030-2045
Hauptverfasser:	Hashitani, Hikaru, Lang, Richard J, Mitsui, Retsu, Mabuchi, Yoshio, Suzuki, Hikaru
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials - drug effects Animals ATP‐sensitive K+ (KATP) channels Calcitonin Gene-Related Peptide - pharmacology Calcium - metabolism Calcium Channels, L-Type - drug effects Calcium Channels, L-Type - metabolism CGRP Humans Immunohistochemistry intracellular calcium KATP Channels - metabolism Kidney Pelvis - cytology Kidney Pelvis - drug effects Kidney Pelvis - metabolism Male Mice Mice, Inbred BALB C Microelectrodes Microscopy, Electron mitochondria Mitochondria - metabolism Muscle Contraction - drug effects Myocytes, Smooth Muscle - drug effects Myocytes, Smooth Muscle - metabolism renal pelvis Research Papers sensory nerve smooth muscle
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