Hedgehog- and Antennapedia-dependent niche maintains Drosophila haematopoietic precursors

The Drosophila melanogaster lymph gland is a haematopoietic organ in which pluripotent blood cell progenitors proliferate and mature into differentiated haemocytes. Previous work has defined three domains, the medullary zone, the cortical zone and the posterior signalling centre (PSC), within the de...

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Veröffentlicht in:	Nature 2007-03, Vol.446 (7133), p.320-324
Hauptverfasser:	Mandal, L, Martinez-Agosto, J.A, Evans, C.J, Hartenstein, V, Banerjee, U
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antennapedia Homeodomain Protein - genetics Antennapedia Homeodomain Protein - metabolism Antp gene Biological and medical sciences Cell Differentiation Cell differentiation, maturation, development, hematopoiesis Cell growth Cell physiology crystal cells Drosophila melanogaster Drosophila melanogaster - anatomy & histology Drosophila melanogaster - cytology Drosophila melanogaster - growth & development Drosophila melanogaster - metabolism Drosophila Proteins - genetics Drosophila Proteins - metabolism Embryos Erythrocytes Fundamental and applied biological sciences. Psychology Gene expression Gene Expression Regulation, Developmental Hedgehog protein Hedgehog Proteins - genetics Hedgehog Proteins - metabolism hematopoiesis Hematopoietic Stem Cells - cytology Hematopoietic Stem Cells - metabolism hemocytes Hemocytes - cytology Hemocytes - metabolism homeotic genes Humanities and Social Sciences Insects Larva - cytology Larva - growth & development Larva - metabolism larvae letter Leukocytes lymph nodes Lymphatic system Lymphatic System - anatomy & histology Lymphatic System - cytology Lymphatic System - growth & development Molecular and cellular biology multidisciplinary plasmatocytes posterior signalling center Science Science (multidisciplinary) transcription factors
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