Determination of extracellular bicarbonate and carbon dioxide concentrations in brain slices using carbonate and pH-selective microelectrodes

The extracellular pH of the brain is subject to shifts during neural activity. To understand these pH changes, it is necessary to measure [H +], [HCO 3 −], [CO 3 2−] and [CO 2]. In principle, this can be accomplished using CO 3 2− and pH-sensitive microelectrodes; however, interference from HCO 3 −...

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