Mitotic arrest-associated apoptosis induced by sodium arsenite in A375 melanoma cells is BUBR1-dependent

A375 human malignant melanoma cells undergo mitotic arrest-associated apoptosis when treated with pharmacological concentrations of sodium arsenite, a chemotherapeutic for acute promyelocytic leukemia. Our previous studies indicated that decreased arsenite sensitivity correlated with reduced mitotic...

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Veröffentlicht in:	Toxicology and applied pharmacology 2008-08, Vol.231 (1), p.61-67
Hauptverfasser:	McNeely, Samuel C., Taylor, B. Frazier, States, J. Christopher
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES Antineoplastic Agents - pharmacology Antineoplastic Agents, Phytogenic - pharmacology APOPTOSIS Apoptosis - drug effects ARSENIC Arsenite Arsenites - toxicity Biological and medical sciences Blotting, Western BORON CHLORIDES CDC2 Protein Kinase - genetics CDC2 Protein Kinase - physiology Chemical and industrial products toxicology. Toxic occupational diseases Dermatology Fluorescent Antibody Technique Humans INHIBITION LEAD LEUKEMIA Medical sciences Melanoma, Experimental - pathology MELANOMAS Metals and various inorganic compounds Mitosis - drug effects Mitotic arrest MITOTIC INDEX Nocodazole - pharmacology Paclitaxel - pharmacology PHOSPHORYLATION Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - physiology PROTEINS Purines - pharmacology RNA, Small Interfering - pharmacology SENSITIVITY SODIUM Sodium Compounds - toxicity Spindle checkpoint Toxicology Tumors of the skin and soft tissue. Premalignant lesions
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