Homeostatic imbalance of regulatory and effector T cells due to IL-2 deprivation amplifies murine lupus

The origins and consequences of a regulatory T cell (Treg) disorder in systemic lupus erythematosus (SLE) are poorly understood. In the (NZBxNZW) F₁ mouse model of lupus, we found that CD4⁺Foxp3⁺ Treg failed to maintain a competitive pool size in the peripheral lymphoid organs resulting in a progres...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2010-01, Vol.107 (1), p.204-209
Hauptverfasser:	Humrich, Jens Y, Morbach, Henner, Undeutsch, Reinmar, Enghard, Philipp, Rosenberger, Stefan, Weigert, Olivia, Kloke, Lutz, Heimann, Juliane, Gaber, Timo, Brandenburg, Susan, Scheffold, Alexander, Huehn, Jochen, Radbruch, Andreas, Burmester, Gerd-Rüdiger, Riemekasten, Gabriela
Format:	Artikel
Sprache:	eng
Schlagworte:	Adoptive Transfer Aging - immunology Animals Biological Sciences CD4-Positive T-Lymphocytes - immunology Cells Disease Models, Animal Disease Progression Female Genotype & phenotype Homeostasis Interleukin-2 - immunology Lupus Lupus Erythematosus, Systemic - immunology Lupus Erythematosus, Systemic - physiopathology Mice Mice, Inbred BALB C Phenotype Rodents T cell receptors T-Lymphocyte Subsets - immunology T-Lymphocytes, Regulatory - immunology
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