Recognition memory signals in the macaque hippocampus
The hippocampus plays a critical role in recognition memory in both monkeys and humans. However, neurophysiological studies have rarely reported recognition memory signals among hippocampal neurons. The majority of these previous studies used variants of the delayed match-to-sample task; however, st...
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| Veröffentlicht in: | Proceedings of the National Academy of Sciences - PNAS 2010-01, Vol.107 (1), p.401-406 |
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| description | The hippocampus plays a critical role in recognition memory in both monkeys and humans. However, neurophysiological studies have rarely reported recognition memory signals among hippocampal neurons. The majority of these previous studies used variants of the delayed match-to-sample task; however, studies of the effects of hippocampal damage in monkey and humans have shown that another task of recognition memory, the visual paired-comparison, or visual preferential looking task (VPLT), is more sensitive to hippocampal damage than the delayed matching tasks. Accordingly, to examine possible recognition memory signals in the hippocampus, we recorded the activity of 131 hippocampal neurons in two monkeys performing the VPLT. Eighty-eight neurons (67%) responded significantly to stimulus presentation relative to the baseline prestimulus period. A substantial proportion of these visually responsive neurons (36%) showed significant firing-rate modulations that reflected whether stimuli were novel or familiar. Additionally, these firing-rate modulations were correlated with recognition memory performance on the VPLT such that larger modulations by stimulus novelty were associated with better performance. Together, these results provide evidence for a neural signal in the hippocampus that may support recognition memory performance. |
| doi_str_mv | 10.1073/pnas.0908378107 |
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Buffalo, Elizabeth A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c487t-607187bf0f7d6c6ba67b19e10a37e41bdd2a02144f9bbba5cee2b27bade098973</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Action Potentials - physiology</topic><topic>Animals</topic><topic>Behavior, Animal - physiology</topic><topic>Behavioral neuroscience</topic><topic>Biological Sciences</topic><topic>Brain</topic><topic>Cognitive neuroscience</topic><topic>Effects</topic><topic>Electrophysiology</topic><topic>Hippocampus</topic><topic>Hippocampus - cytology</topic><topic>Hippocampus - physiology</topic><topic>Humans</topic><topic>Lesions</topic><topic>Macaca mulatta</topic><topic>Male</topic><topic>Memory</topic><topic>Memory - physiology</topic><topic>Mental Recall - physiology</topic><topic>Mental stimulation</topic><topic>Monkeys & apes</topic><topic>Neurons</topic><topic>Neurons - cytology</topic><topic>Neurons - physiology</topic><topic>Primates</topic><topic>Reaction Time - physiology</topic><topic>Recognition memory</topic><topic>Visual stimulation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jutras, Michael J</creatorcontrib><creatorcontrib>Buffalo, Elizabeth A</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jutras, Michael J</au><au>Buffalo, Elizabeth A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Recognition memory signals in the macaque hippocampus</atitle><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle><addtitle>Proc Natl Acad Sci U S A</addtitle><date>2010-01-05</date><risdate>2010</risdate><volume>107</volume><issue>1</issue><spage>401</spage><epage>406</epage><pages>401-406</pages><issn>0027-8424</issn><eissn>1091-6490</eissn><abstract>The hippocampus plays a critical role in recognition memory in both monkeys and humans. 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| subjects | Action Potentials - physiology Animals Behavior, Animal - physiology Behavioral neuroscience Biological Sciences Brain Cognitive neuroscience Effects Electrophysiology Hippocampus Hippocampus - cytology Hippocampus - physiology Humans Lesions Macaca mulatta Male Memory Memory - physiology Mental Recall - physiology Mental stimulation Monkeys & apes Neurons Neurons - cytology Neurons - physiology Primates Reaction Time - physiology Recognition memory Visual stimulation |
| title | Recognition memory signals in the macaque hippocampus |
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