NCLX is an essential component of mitochondrial Na⁺/Ca²⁺ exchange

Mitochondrial Ca²⁺ efflux is linked to numerous cellular activities and pathophysiological processes. Although it is established that an Na⁺-dependent mechanism mediates mitochondrial Ca²⁺ efflux, the molecular identity of this transporter has remained elusive. Here we show that the Na⁺/Ca²⁺ exchang...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2010-01, Vol.107 (1), p.436-441
Hauptverfasser:	Palty, Raz, Silverman, William F, Hershfinkel, Michal, Caporale, Teresa, Sensi, Stefano L, Parnis, Julia, Nolte, Christiane, Fishman, Daniel, Shoshan-Barmatz, Varda, Herrmann, Sharon, Khananshvili, Daniel, Sekler, Israel
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological Sciences Brain - cytology Brain - metabolism Calcium Calcium - metabolism Cell membranes CHO cells Clonazepam - analogs & derivatives Clonazepam - metabolism Fluorescence Hepatocytes Homeostasis Humans Mice Mitochondria Mitochondria - metabolism Mitochondria - ultrastructure Mitochondrial Membranes - metabolism Mitochondrial Membranes - ultrastructure Myocardium - cytology Myocardium - metabolism Plasmids Protein isoforms Rats Sodium - metabolism Sodium-Calcium Exchanger - antagonists & inhibitors Sodium-Calcium Exchanger - genetics Sodium-Calcium Exchanger - metabolism Thiazepines - metabolism Wavelengths
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