The role of p38b MAPK in age-related modulation of intestinal stem cell proliferation and differentiation in Drosophila
It is important to understand how age-related changes in intestinal stem cells (ISCs) may contribute to age-associated intestinal diseases, including cancer. Drosophila midgut is an excellent model system for the study of ISC proliferation and differentiation. Recently, age-related changes in the Dr...
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| Veröffentlicht in: | Aging (Albany, NY.) NY.), 2009-05, Vol.1 (7), p.637-651 |
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| creator | Park, Joung-Sun Kim, Young-Shin Yoo, Mi-Ae |
| description | It is important to understand how age-related changes in intestinal stem cells (ISCs) may contribute to age-associated intestinal diseases, including cancer. Drosophila midgut is an excellent model system for the study of ISC proliferation and differentiation. Recently, age-related changes in the Drosophila midgut have been shown to include an increase in ISC proliferation and accumulation of mis-differentiated ISC daughter cells. Here, we show that the p38b MAPK pathway contributes to the age-related changes in ISC and progenitor cells in Drosophila. D-p38b MAPK is required for an age-related increase of ISC proliferation. In addition, this pathway is involved in age and oxidative stress-associated mis-differentiation of enterocytes and upregulation of Delta, a Notch receptor ligand. Furthermore, we also show that D-p38b acts downstream of PVF2/PVR signaling in these age-related changes. Taken together, our findings suggest that p38 MAPK plays a crucial role in the balance between ISC proliferation and proper differentiation in the adult Drosophila midgut. |
| doi_str_mv | 10.18632/aging.100054 |
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Drosophila midgut is an excellent model system for the study of ISC proliferation and differentiation. Recently, age-related changes in the Drosophila midgut have been shown to include an increase in ISC proliferation and accumulation of mis-differentiated ISC daughter cells. Here, we show that the p38b MAPK pathway contributes to the age-related changes in ISC and progenitor cells in Drosophila. D-p38b MAPK is required for an age-related increase of ISC proliferation. In addition, this pathway is involved in age and oxidative stress-associated mis-differentiation of enterocytes and upregulation of Delta, a Notch receptor ligand. Furthermore, we also show that D-p38b acts downstream of PVF2/PVR signaling in these age-related changes. Taken together, our findings suggest that p38 MAPK plays a crucial role in the balance between ISC proliferation and proper differentiation in the adult Drosophila midgut.</description><identifier>ISSN: 1945-4589</identifier><identifier>EISSN: 1945-4589</identifier><identifier>DOI: 10.18632/aging.100054</identifier><identifier>PMID: 20157545</identifier><language>eng</language><publisher>United States: Impact Journals LLC</publisher><subject>Adult Stem Cells - cytology ; Adult Stem Cells - metabolism ; Aging - physiology ; Animals ; Animals, Genetically Modified - physiology ; Cell Differentiation - drug effects ; Cell Differentiation - physiology ; Cell Proliferation ; Drosophila melanogaster - cytology ; Drosophila melanogaster - enzymology ; Drosophila Proteins - genetics ; Drosophila Proteins - metabolism ; Enterocytes - cytology ; Enterocytes - metabolism ; Enteroendocrine Cells - cytology ; Enteroendocrine Cells - metabolism ; Gene Expression - genetics ; Intestinal Mucosa - metabolism ; Intestines - cytology ; Intracellular Signaling Peptides and Proteins ; Membrane Proteins - genetics ; Membrane Proteins - metabolism ; Mitogen-Activated Protein Kinase 11 - genetics ; Mitogen-Activated Protein Kinase 11 - metabolism ; Nerve Tissue Proteins - genetics ; Nerve Tissue Proteins - metabolism ; Nuclear Proteins - genetics ; Nuclear Proteins - metabolism ; Oxidative Stress - physiology ; Paraquat - pharmacology ; Receptor Protein-Tyrosine Kinases - genetics ; Receptor Protein-Tyrosine Kinases - metabolism ; Repressor Proteins - genetics ; Repressor Proteins - metabolism ; Signal Transduction - physiology ; Stem Cells - cytology ; Stem Cells - metabolism ; Transcription Factors - genetics ; Transcription Factors - metabolism</subject><ispartof>Aging (Albany, NY.), 2009-05, Vol.1 (7), p.637-651</ispartof><rights>Copyright: ©2009 Park et al. 2009</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c452t-8254a5aaafa9a6895e1c3ca2bed3ef4fd0a9146e91458a6a5535741b798a48403</citedby><cites>FETCH-LOGICAL-c452t-8254a5aaafa9a6895e1c3ca2bed3ef4fd0a9146e91458a6a5535741b798a48403</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2806044/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2806044/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20157545$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Park, Joung-Sun</creatorcontrib><creatorcontrib>Kim, Young-Shin</creatorcontrib><creatorcontrib>Yoo, Mi-Ae</creatorcontrib><title>The role of p38b MAPK in age-related modulation of intestinal stem cell proliferation and differentiation in Drosophila</title><title>Aging (Albany, NY.)</title><addtitle>Aging (Albany NY)</addtitle><description>It is important to understand how age-related changes in intestinal stem cells (ISCs) may contribute to age-associated intestinal diseases, including cancer. Drosophila midgut is an excellent model system for the study of ISC proliferation and differentiation. Recently, age-related changes in the Drosophila midgut have been shown to include an increase in ISC proliferation and accumulation of mis-differentiated ISC daughter cells. Here, we show that the p38b MAPK pathway contributes to the age-related changes in ISC and progenitor cells in Drosophila. D-p38b MAPK is required for an age-related increase of ISC proliferation. In addition, this pathway is involved in age and oxidative stress-associated mis-differentiation of enterocytes and upregulation of Delta, a Notch receptor ligand. Furthermore, we also show that D-p38b acts downstream of PVF2/PVR signaling in these age-related changes. Taken together, our findings suggest that p38 MAPK plays a crucial role in the balance between ISC proliferation and proper differentiation in the adult Drosophila midgut.</description><subject>Adult Stem Cells - cytology</subject><subject>Adult Stem Cells - metabolism</subject><subject>Aging - physiology</subject><subject>Animals</subject><subject>Animals, Genetically Modified - physiology</subject><subject>Cell Differentiation - drug effects</subject><subject>Cell Differentiation - physiology</subject><subject>Cell Proliferation</subject><subject>Drosophila melanogaster - cytology</subject><subject>Drosophila melanogaster - enzymology</subject><subject>Drosophila Proteins - genetics</subject><subject>Drosophila Proteins - metabolism</subject><subject>Enterocytes - cytology</subject><subject>Enterocytes - metabolism</subject><subject>Enteroendocrine Cells - cytology</subject><subject>Enteroendocrine Cells - metabolism</subject><subject>Gene Expression - genetics</subject><subject>Intestinal Mucosa - metabolism</subject><subject>Intestines - cytology</subject><subject>Intracellular Signaling Peptides and Proteins</subject><subject>Membrane Proteins - genetics</subject><subject>Membrane Proteins - metabolism</subject><subject>Mitogen-Activated Protein Kinase 11 - genetics</subject><subject>Mitogen-Activated Protein Kinase 11 - metabolism</subject><subject>Nerve Tissue Proteins - genetics</subject><subject>Nerve Tissue Proteins - metabolism</subject><subject>Nuclear Proteins - genetics</subject><subject>Nuclear Proteins - metabolism</subject><subject>Oxidative Stress - physiology</subject><subject>Paraquat - pharmacology</subject><subject>Receptor Protein-Tyrosine Kinases - genetics</subject><subject>Receptor Protein-Tyrosine Kinases - metabolism</subject><subject>Repressor Proteins - genetics</subject><subject>Repressor Proteins - metabolism</subject><subject>Signal Transduction - physiology</subject><subject>Stem Cells - cytology</subject><subject>Stem Cells - metabolism</subject><subject>Transcription Factors - genetics</subject><subject>Transcription Factors - metabolism</subject><issn>1945-4589</issn><issn>1945-4589</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkc1v3CAQxVHVqPloj71W3HpyAobx4kulKN_KRukhPaNZe7xLZYML3lb578PGaZRcmGH46TFPj7GvUhxLU6nyBNfOr4-lEAL0B3Ygaw2FBlN_fNPvs8OUfgtRAejqE9svhYQFaDhg_x42xGPoiYeOj8qs-N3pz1vuPMc1FZF6nKjlQ2i3uXPB7zDnJ0qT89jzNNHAG-p7PmYR11GcKfQtb12X7-QnN8-y5nkMKYwb1-Nnttdhn-jLSz1ivy4vHs6ui-X91c3Z6bJoNJRTYUrQCIjYYY2VqYFkoxosV9Qq6nTXCqylrigfYLBCAAULLVeL2qA2Wqgj9mPWHbergdomrxOxt2N0A8ZHG9DZ9y_ebew6_LWlEZXQOgt8fxGI4c82-7aDSzvH6Clsk10oVdVQG8hkMZNNdpkida-_SGGfs7LPWdk5q8x_e7vaK_0_HPUE0XmS1g</recordid><startdate>20090521</startdate><enddate>20090521</enddate><creator>Park, Joung-Sun</creator><creator>Kim, Young-Shin</creator><creator>Yoo, Mi-Ae</creator><general>Impact Journals LLC</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20090521</creationdate><title>The role of p38b MAPK in age-related modulation of intestinal stem cell proliferation and differentiation in Drosophila</title><author>Park, Joung-Sun ; Kim, Young-Shin ; Yoo, Mi-Ae</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c452t-8254a5aaafa9a6895e1c3ca2bed3ef4fd0a9146e91458a6a5535741b798a48403</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adult Stem Cells - cytology</topic><topic>Adult Stem Cells - metabolism</topic><topic>Aging - physiology</topic><topic>Animals</topic><topic>Animals, Genetically Modified - physiology</topic><topic>Cell Differentiation - drug effects</topic><topic>Cell Differentiation - physiology</topic><topic>Cell Proliferation</topic><topic>Drosophila melanogaster - cytology</topic><topic>Drosophila melanogaster - enzymology</topic><topic>Drosophila Proteins - genetics</topic><topic>Drosophila Proteins - metabolism</topic><topic>Enterocytes - cytology</topic><topic>Enterocytes - metabolism</topic><topic>Enteroendocrine Cells - cytology</topic><topic>Enteroendocrine Cells - metabolism</topic><topic>Gene Expression - genetics</topic><topic>Intestinal Mucosa - metabolism</topic><topic>Intestines - cytology</topic><topic>Intracellular Signaling Peptides and Proteins</topic><topic>Membrane Proteins - genetics</topic><topic>Membrane Proteins - metabolism</topic><topic>Mitogen-Activated Protein Kinase 11 - genetics</topic><topic>Mitogen-Activated Protein Kinase 11 - metabolism</topic><topic>Nerve Tissue Proteins - genetics</topic><topic>Nerve Tissue Proteins - metabolism</topic><topic>Nuclear Proteins - genetics</topic><topic>Nuclear Proteins - metabolism</topic><topic>Oxidative Stress - physiology</topic><topic>Paraquat - pharmacology</topic><topic>Receptor Protein-Tyrosine Kinases - genetics</topic><topic>Receptor Protein-Tyrosine Kinases - metabolism</topic><topic>Repressor Proteins - genetics</topic><topic>Repressor Proteins - metabolism</topic><topic>Signal Transduction - physiology</topic><topic>Stem Cells - cytology</topic><topic>Stem Cells - metabolism</topic><topic>Transcription Factors - genetics</topic><topic>Transcription Factors - metabolism</topic><toplevel>online_resources</toplevel><creatorcontrib>Park, Joung-Sun</creatorcontrib><creatorcontrib>Kim, Young-Shin</creatorcontrib><creatorcontrib>Yoo, Mi-Ae</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Aging (Albany, NY.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Park, Joung-Sun</au><au>Kim, Young-Shin</au><au>Yoo, Mi-Ae</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The role of p38b MAPK in age-related modulation of intestinal stem cell proliferation and differentiation in Drosophila</atitle><jtitle>Aging (Albany, NY.)</jtitle><addtitle>Aging (Albany NY)</addtitle><date>2009-05-21</date><risdate>2009</risdate><volume>1</volume><issue>7</issue><spage>637</spage><epage>651</epage><pages>637-651</pages><issn>1945-4589</issn><eissn>1945-4589</eissn><abstract>It is important to understand how age-related changes in intestinal stem cells (ISCs) may contribute to age-associated intestinal diseases, including cancer. Drosophila midgut is an excellent model system for the study of ISC proliferation and differentiation. Recently, age-related changes in the Drosophila midgut have been shown to include an increase in ISC proliferation and accumulation of mis-differentiated ISC daughter cells. Here, we show that the p38b MAPK pathway contributes to the age-related changes in ISC and progenitor cells in Drosophila. D-p38b MAPK is required for an age-related increase of ISC proliferation. In addition, this pathway is involved in age and oxidative stress-associated mis-differentiation of enterocytes and upregulation of Delta, a Notch receptor ligand. Furthermore, we also show that D-p38b acts downstream of PVF2/PVR signaling in these age-related changes. Taken together, our findings suggest that p38 MAPK plays a crucial role in the balance between ISC proliferation and proper differentiation in the adult Drosophila midgut.</abstract><cop>United States</cop><pub>Impact Journals LLC</pub><pmid>20157545</pmid><doi>10.18632/aging.100054</doi><tpages>15</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Stem Cells - cytology Adult Stem Cells - metabolism Aging - physiology Animals Animals, Genetically Modified - physiology Cell Differentiation - drug effects Cell Differentiation - physiology Cell Proliferation Drosophila melanogaster - cytology Drosophila melanogaster - enzymology Drosophila Proteins - genetics Drosophila Proteins - metabolism Enterocytes - cytology Enterocytes - metabolism Enteroendocrine Cells - cytology Enteroendocrine Cells - metabolism Gene Expression - genetics Intestinal Mucosa - metabolism Intestines - cytology Intracellular Signaling Peptides and Proteins Membrane Proteins - genetics Membrane Proteins - metabolism Mitogen-Activated Protein Kinase 11 - genetics Mitogen-Activated Protein Kinase 11 - metabolism Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Nuclear Proteins - genetics Nuclear Proteins - metabolism Oxidative Stress - physiology Paraquat - pharmacology Receptor Protein-Tyrosine Kinases - genetics Receptor Protein-Tyrosine Kinases - metabolism Repressor Proteins - genetics Repressor Proteins - metabolism Signal Transduction - physiology Stem Cells - cytology Stem Cells - metabolism Transcription Factors - genetics Transcription Factors - metabolism |
| title | The role of p38b MAPK in age-related modulation of intestinal stem cell proliferation and differentiation in Drosophila |
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