The TC10-Exo70 Complex Is Essential for Membrane Expansion and Axonal Specification in Developing Neurons

Axonal elongation is one of the hallmarks of neuronal polarization. This phenomenon requires axonal membrane growth by exocytosis of plasmalemmal precursor vesicles (PPVs) at the nerve growth cone, a process regulated by IGF-1 activation of the PI3K (phosphatidylinositol-3 kinase) pathway. Few detai...

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Veröffentlicht in:	The Journal of neuroscience 2009-10, Vol.29 (42), p.13292-13301
Hauptverfasser:	Dupraz, Sebastian, Grassi, Diego, Bernis, Maria Eugenia, Sosa, Lucas, Bisbal, Mariano, Gastaldi, Laura, Jausoro, Ignacio, Caceres, Alfredo, Pfenninger, Karl H, Quiroga, Santiago
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Axons - drug effects Axons - physiology Axons - ultrastructure Cells, Cultured Cellular Structures - drug effects Cellular Structures - metabolism Chromones - pharmacology Embryo, Mammalian Enzyme Activation - drug effects Enzyme Inhibitors - pharmacology Green Fluorescent Proteins - genetics Hippocampus - cytology Insulin-Like Growth Factor I - pharmacology Morpholines - pharmacology Protein Transport - drug effects Protein Transport - physiology Pyramidal Cells - cytology Rats Receptor, IGF Type 1 - physiology rho GTP-Binding Proteins - metabolism RNA, Small Interfering - genetics RNA, Small Interfering - metabolism Time Factors Transfection - methods Vesicular Transport Proteins - metabolism
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