Antioxidant-induced Phosphorylation of Tyrosine 486 Leads to Rapid Nuclear Export of Bach1 That Allows Nrf2 to Bind to the Antioxidant Response Element and Activate Defensive Gene Expression

Antioxidants cause stabilization and nuclear translocation of NF-E2-related factor 2 (Nrf2), where it binds to the antioxidant response element (ARE) and induces up-regulation of defensive genes that protect cells against oxidative and electrophilic stress. Bach1, the negative regulator of Nrf2, com...

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Veröffentlicht in:	The Journal of biological chemistry 2010-01, Vol.285 (1), p.153-162
Hauptverfasser:	Kaspar, James W., Jaiswal, Anil K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Active Transport, Cell Nucleus - drug effects Animals Antioxidants - pharmacology Basic-Leucine Zipper Transcription Factors - chemistry Basic-Leucine Zipper Transcription Factors - genetics Basic-Leucine Zipper Transcription Factors - metabolism Cadmium - pharmacology Cell Nucleus - drug effects Cell Nucleus - metabolism Cycloheximide - pharmacology Enzymes Exportin 1 Protein Fanconi Anemia Complementation Group Proteins - chemistry Fanconi Anemia Complementation Group Proteins - genetics Fanconi Anemia Complementation Group Proteins - metabolism Gene Expression Regulation - drug effects Gene/Regulation Hep G2 Cells Humans Hydroquinones - pharmacology Karyopherins - metabolism Mechanisms of Signal Transduction Mice Mutant Proteins Mutation - genetics NAD(P)H Dehydrogenase (Quinone) - metabolism NF-E2-Related Factor 2 - metabolism Nucleus/Nuclear Export Oxygen/Antioxidant Phosphorylation - drug effects Phosphorylation/Kinases/Tyrosine Phosphotyrosine - metabolism Protein Binding - drug effects Protein Kinase Inhibitors - pharmacology Protein Structure, Tertiary Protein/Protein-Protein Interactions Receptors, Cytoplasmic and Nuclear - metabolism Response Elements - genetics RNA, Messenger - genetics RNA, Messenger - metabolism Signal Transduction
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