Mechanisms of fibrinogen-induced microvascular dysfunction during cardiovascular disease

Fibrinogen (Fg) is a high molecular weight plasma adhesion protein and a biomarker of inflammation. Many cardiovascular and cerebrovascular disorders are accompanied by increased blood content of Fg. Increased levels of Fg result in changes in blood rheological properties such as increases in plasma...

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Veröffentlicht in:	Acta Physiologica 2010-01, Vol.198 (1), p.1-13
Hauptverfasser:	Lominadze, D, Dean, W.L, Tyagi, S.C, Roberts, A.M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals arteriolar constriction Biological and medical sciences Blood Viscosity - physiology Cardiovascular Diseases - metabolism Cardiovascular Diseases - physiopathology endothelial cell layer permeability endothelin-1 erythrocyte aggregation Erythrocyte Aggregation - physiology Fibrinogen - metabolism Fundamental and applied biological sciences. Psychology Humans Microcirculation - physiology tight junction proteins Vertebrates: anatomy and physiology, studies on body, several organs or systems Weibel-Palade body exocytosis
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