Mammalian miRNA RISC Recruits CAF1 and PABP to Affect PABP-Dependent Deadenylation

MicroRNAs (miRNAs) inhibit mRNA expression in general by base pairing to the 3′UTR of target mRNAs and consequently inhibiting translation and/or initiating poly(A) tail deadenylation and mRNA destabilization. Here we examine the mechanism and kinetics of miRNA-mediated deadenylation in mouse Krebs-...

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Veröffentlicht in:	Molecular cell 2009-09, Vol.35 (6), p.868-880
Hauptverfasser:	Fabian, Marc R., Mathonnet, Géraldine, Sundermeier, Thomas, Mathys, Hansruedi, Zipprich, Jakob T., Svitkin, Yuri V., Rivas, Fabiola, Jinek, Martin, Wohlschlegel, James, Doudna, Jennifer A., Chen, Chyi-Ying A., Shyu, Ann-Bin, Yates, John R., Hannon, Gregory J., Filipowicz, Witold, Duchaine, Thomas F., Sonenberg, Nahum
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Argonaute Proteins Ascites - genetics Ascites - metabolism Autoantigens - metabolism Binding Sites Carcinoma, Krebs 2 - genetics Carcinoma, Krebs 2 - metabolism Cell-Free System Eukaryotic Initiation Factor-2 - metabolism Eukaryotic Initiation Factor-4G - metabolism Gene Silencing HeLa Cells Humans Kinetics Mice MicroRNAs - metabolism Poly(A)-Binding Proteins - genetics Poly(A)-Binding Proteins - metabolism Protein Biosynthesis Protein Structure, Tertiary PROTEINS Proteins - genetics Proteins - metabolism Receptors, CCR4 - metabolism RNA RNA Processing, Post-Transcriptional RNA Stability RNA, Messenger - metabolism RNA-Induced Silencing Complex - genetics RNA-Induced Silencing Complex - metabolism Transfection
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