Genome-wide autozygosity mapping in human populations

Individuals are frequently observed to have long segments of uninterrupted sequences of homozygous markers. One of the major mechanisms that gives rise to such long homozygous segments is consanguineous marriages, where parents pass shared chromosomal segments to their child. Such chromosomal segmen...

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Veröffentlicht in:	Genetic epidemiology 2009-02, Vol.33 (2), p.172-180
Hauptverfasser:	Wang, Shuang, Haynes, Chad, Barany, Francis, Ott, Jurg
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Alleles autozygosity Chromosome Mapping - statistics & numerical data Chromosomes, Human, Pair 20 - genetics Consanguinity Female Gene Frequency Genetics, Medical - statistics & numerical data Genome, Human Genome-Wide Association Study - statistics & numerical data homozygosity Homozygote Humans IBD Lod Score Male Molecular Epidemiology - statistics & numerical data Parkinson Disease - genetics Polymorphism, Single Nucleotide
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