Role of FRNK tyrosine phosphorylation in vascular smooth muscle spreading and migration

Aims Focal adhesion kinase (FAK) and its autonomously expressed, C-terminal inhibitor FAK-related non-kinase (FRNK), are important regulators of vascular smooth muscle cell (VSMC) spreading and migration. However, the mechanisms of FRNK-mediated inhibition of FAK-dependent signalling are not fully d...

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Veröffentlicht in:	Cardiovascular research 2010-02, Vol.85 (3), p.571-581
Hauptverfasser:	Koshman, Yevgeniya E., Engman, Steven J., Kim, Taehoon, Iyengar, Rekha, Henderson, Kyle K., Samarel, Allen M.
Format:	Artikel
Sprache:	eng
Schlagworte:	A7r5 Animals Biological and medical sciences Cardiology. Vascular system Cell Movement Cells, Cultured FAK-related non-kinase Focal adhesion kinase Focal Adhesion Protein-Tyrosine Kinases - physiology Focal Adhesions Medical sciences Muscle, Smooth, Vascular - cytology Myocytes, Smooth Muscle - physiology Original Phosphorylation Protein-Tyrosine Kinases - metabolism Rats Signal transduction Tyrosine - metabolism
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