Identification of KCNJ15 as a Susceptibility Gene in Asian Patients with Type 2 Diabetes Mellitus

Recent advances in genome research have enabled the identification of new genomic variations that are associated with type 2 diabetes mellitus (T2DM). Via fine mapping of SNPs in a candidate region of chromosome 21q, the current study identifies potassium inwardly-rectifying channel, subfamily J, me...

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Veröffentlicht in:	American journal of human genetics 2010, Vol.86 (1), p.54-64
Hauptverfasser:	Okamoto, Koji, Iwasaki, Naoko, Nishimura, Chisa, Doi, Kent, Noiri, Eisei, Nakamura, Shinko, Takizawa, Miho, Ogata, Makiko, Fujimaki, Risa, Grarup, Niels, Pisinger, Charlotta, Borch-Johnsen, Knut, Lauritzen, Torsten, Sandbaek, Annelli, Hansen, Torben, Yasuda, Kazuki, Osawa, Haruhiko, Nanjo, Kishio, Kadowaki, Takashi, Kasuga, Masato, Pedersen, Oluf, Fujita, Toshiro, Kamatani, Naoyuki, Iwamoto, Yasuhiko, Tokunaga, Katsushi
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Asian People Biological and medical sciences Biological variation Case-Control Studies Chromosomes Chromosomes, Human, Pair 21 Diabetes Diabetes Mellitus, Type 2 - ethnology Diabetes Mellitus, Type 2 - genetics Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Female Fundamental and applied biological sciences. Psychology Gene expression General aspects. Genetic counseling Genetic Predisposition to Disease Genetics of eukaryotes. Biological and molecular evolution Genomics Humans Insulin-Secreting Cells - metabolism Kidneys Male Medical genetics Medical sciences Middle Aged Molecular and cellular biology Patients Polymorphism, Single Nucleotide Potassium Channels, Inwardly Rectifying - genetics Potassium Channels, Inwardly Rectifying - physiology Proteins
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