Glomerular Density in Renal Biopsy Specimens Predicts the Long-Term Prognosis of IgA Nephropathy

An early histopathologic predictor of the renal prognosis, before the occurrence of advanced glomerular sclerosis/interstitial fibrosis and/or apparent renal dysfunction, remains to be established in IgA nephropathy (IgAN). This study aimed to determine whether the glomerular density (GD; nonsclerot...

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Veröffentlicht in:Clinical journal of the American Society of Nephrology 2010-01, Vol.5 (1), p.39-44
Hauptverfasser: Tsuboi, Nobuo, Kawamura, Tetsuya, Koike, Kentaro, Okonogi, Hideo, Hirano, Keita, Hamaguchi, Akihiko, Miyazaki, Yoichi, Ogura, Makoto, Joh, Kensuke, Utsunomiya, Yasunori, Hosoya, Tatsuo
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container_title Clinical journal of the American Society of Nephrology
container_volume 5
creator Tsuboi, Nobuo
Kawamura, Tetsuya
Koike, Kentaro
Okonogi, Hideo
Hirano, Keita
Hamaguchi, Akihiko
Miyazaki, Yoichi
Ogura, Makoto
Joh, Kensuke
Utsunomiya, Yasunori
Hosoya, Tatsuo
description An early histopathologic predictor of the renal prognosis, before the occurrence of advanced glomerular sclerosis/interstitial fibrosis and/or apparent renal dysfunction, remains to be established in IgA nephropathy (IgAN). This study aimed to determine whether the glomerular density (GD; nonsclerotic glomerular number per renal cortical area) of biopsy specimens obtained at an early stage of IgAN could predict the long-term renal outcome. The predictive value of the factors at biopsy, including the GD, on the renal outcome was retrospectively analyzed for 98 patients who had IgAN with an estimated GFR of > or =60 ml/min per 1.73 m(2) at biopsy (87 ml/min per 1.73 m(2) on average). The individual value of GD in biopsy ranged from 1.2 to 8.1/mm(2) (i.e., approximately a seven-fold variation), and the GD showed a close inverse correlation with mean glomerular volume. Among the various clinicopathologic factors involved, both a cellular/fibrocellular crescent and the GD were found to be significant predictors of progression in multivariate analyses. A low GD in the biopsy specimens was frequently associated with a steeper slope of the renal function and a synergistically enhanced risk for progression with the presence of cellular/fibrocellular crescent. The renal function, proteinuria, degrees of glomerulosclerosis, and interstitial fibrosis at biopsy were not independent predictors of the prognosis in these patients. A strong predictive relationship of low GD with progression observed in this study suggests that GD may serve as an early histopathologic marker of long-term renal prognosis in IgAN.
doi_str_mv 10.2215/CJN.04680709
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A low GD in the biopsy specimens was frequently associated with a steeper slope of the renal function and a synergistically enhanced risk for progression with the presence of cellular/fibrocellular crescent. The renal function, proteinuria, degrees of glomerulosclerosis, and interstitial fibrosis at biopsy were not independent predictors of the prognosis in these patients. 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A low GD in the biopsy specimens was frequently associated with a steeper slope of the renal function and a synergistically enhanced risk for progression with the presence of cellular/fibrocellular crescent. The renal function, proteinuria, degrees of glomerulosclerosis, and interstitial fibrosis at biopsy were not independent predictors of the prognosis in these patients. A strong predictive relationship of low GD with progression observed in this study suggests that GD may serve as an early histopathologic marker of long-term renal prognosis in IgAN.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Biopsy</subject><subject>Child</subject><subject>Female</subject><subject>Glomerulonephritis, IGA - pathology</subject><subject>Humans</subject><subject>Kidney Glomerulus - pathology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Original</subject><subject>Predictive Value of Tests</subject><subject>Prognosis</subject><subject>Retrospective Studies</subject><subject>Time Factors</subject><subject>Young Adult</subject><issn>1555-9041</issn><issn>1555-905X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkU1v1DAQhi0Eoh9w41z5gnppih1_JLlU2i5QilYFQZG4ubYzm7hy7GBnQfvvCdqlhdOMZh69M9KD0CtKzsuSijfLjzfnhMuaVKR5gg6pEKJoiPj-9KHn9AAd5XxPCOesFM_RAW0aKQQvD9HdlY8DpI3XCb-FkN20xS7gLxC0x5cujnmLv45g3TAv8ecErbNTxlMPeBVDV9xCGuZx7ELMLuO4xtfdAt_A2Kc46qnfvkDP1tpneLmvx-jb-3e3yw_F6tPV9XKxKiynbCq40YY1pqQVb6uqlkxyaji1jWEagFWyXbeEGtMKAZbVlWQtBWi5FSU3lWzYMbrY5Y4bM0BrIUxJezUmN-i0VVE79f8muF518acqa0KlqOeA031Aij82kCc1uGzBex0gbrKqGJOUUSpn8mxH2hRzTrB-uEKJ-uNEzU7UXyczfvLvZ4_wXsIMvN4Bvev6Xy6ByoP2fsZLZe91DkJRxRr2GwEwlgo</recordid><startdate>20100101</startdate><enddate>20100101</enddate><creator>Tsuboi, Nobuo</creator><creator>Kawamura, Tetsuya</creator><creator>Koike, Kentaro</creator><creator>Okonogi, Hideo</creator><creator>Hirano, Keita</creator><creator>Hamaguchi, Akihiko</creator><creator>Miyazaki, Yoichi</creator><creator>Ogura, Makoto</creator><creator>Joh, Kensuke</creator><creator>Utsunomiya, Yasunori</creator><creator>Hosoya, Tatsuo</creator><general>American Society of Nephrology</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20100101</creationdate><title>Glomerular Density in Renal Biopsy Specimens Predicts the Long-Term Prognosis of IgA Nephropathy</title><author>Tsuboi, Nobuo ; 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subjects Adolescent
Adult
Biopsy
Child
Female
Glomerulonephritis, IGA - pathology
Humans
Kidney Glomerulus - pathology
Male
Middle Aged
Multivariate Analysis
Original
Predictive Value of Tests
Prognosis
Retrospective Studies
Time Factors
Young Adult
title Glomerular Density in Renal Biopsy Specimens Predicts the Long-Term Prognosis of IgA Nephropathy
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