Interplay of Drug Metabolism and Transport: A Real Phenomenon or an Artifact of the Site of Measurement?

The interdependence of both transport and metabolism on the disposition of drugs has recently gained heightened attention in the literature, and has been termed the “interplay of transport and metabolism”. Such “interplay” is observed when inhibition of biliary clearance of a drug results in an “app...

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Veröffentlicht in:	Molecular pharmaceutics 2009-12, Vol.6 (6), p.1756-1765
Hauptverfasser:	Endres, Christopher J, Endres, Michael G, Unadkat, Jashvant D
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological Transport - physiology Humans Liver - metabolism Models, Biological Models, Theoretical Pharmaceutical Preparations - metabolism
Online-Zugang:	Volltext
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