Notch Directly Regulates Gata3 Expression during T Helper 2 Cell Differentiation
Notch signaling plays multiple roles to direct diverse decisions regarding cell fate during T cell development. During helper T (Th) cell differentiation, Notch is involved in generating optimal Th2 cell responses. Here, we present data investigating how Notch mediates Th2 cell differentiation. Notc...
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| Veröffentlicht in: | Immunity (Cambridge, Mass.) Mass.), 2007-07, Vol.27 (1), p.100-110 |
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| creator | Fang, Terry C. Yashiro-Ohtani, Yumi Del Bianco, Cristina Knoblock, Dawson M. Blacklow, Stephen C. Pear, Warren S. |
| description | Notch signaling plays multiple roles to direct diverse decisions regarding cell fate during T cell development. During helper T (Th) cell differentiation, Notch is involved in generating optimal Th2 cell responses. Here, we present data investigating how Notch mediates Th2 cell differentiation. Notch showed a CD4
+ T cell intrinsic role in promoting IL-4 expression that required GATA-3. In the absence of Notch signals,
Gata3 expression was markedly diminished. Introduction of an activated allele of Notch1 into CD4
+ T cells led to the specific and direct upregulation of a developmentally regulated
Gata3 transcript that included the exon 1a sequences. Furthermore, Notch acted in parallel with GATA-3 to synergistically activate IL-4 expression. Together, these data implicate
Gata3 as a direct transcriptional Notch target that acts in concert with Notch signaling to generate optimal Th2 cell responses. |
| doi_str_mv | 10.1016/j.immuni.2007.04.018 |
| format | Article |
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+ T cell intrinsic role in promoting IL-4 expression that required GATA-3. In the absence of Notch signals,
Gata3 expression was markedly diminished. Introduction of an activated allele of Notch1 into CD4
+ T cells led to the specific and direct upregulation of a developmentally regulated
Gata3 transcript that included the exon 1a sequences. Furthermore, Notch acted in parallel with GATA-3 to synergistically activate IL-4 expression. Together, these data implicate
Gata3 as a direct transcriptional Notch target that acts in concert with Notch signaling to generate optimal Th2 cell responses.</description><identifier>ISSN: 1074-7613</identifier><identifier>EISSN: 1097-4180</identifier><identifier>DOI: 10.1016/j.immuni.2007.04.018</identifier><identifier>PMID: 17658278</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animals ; Cell culture ; Cell Differentiation - immunology ; CELLIMMUNO ; Cells, Cultured ; Deoxyribonucleic acid ; DNA ; DNA methylation ; Down-Regulation - immunology ; GATA3 Transcription Factor - antagonists & inhibitors ; GATA3 Transcription Factor - biosynthesis ; GATA3 Transcription Factor - genetics ; GATA3 Transcription Factor - metabolism ; Gene Expression Regulation - immunology ; Genetic testing ; Lymphocytes ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Mice, Knockout ; Mice, Transgenic ; MOLIMMUNO ; Receptors, Notch - physiology ; Signal Transduction - immunology ; T cell receptors ; Th2 Cells - cytology ; Th2 Cells - immunology ; Th2 Cells - metabolism ; Transcription factors</subject><ispartof>Immunity (Cambridge, Mass.), 2007-07, Vol.27 (1), p.100-110</ispartof><rights>2007 Elsevier Inc.</rights><rights>Copyright Elsevier Limited Jul 27, 2007</rights><rights>2007 Elsevier Inc. All rights reserved. 2007</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c520t-bb2675d4d51b687fa4c669efa0bbdf85d0f6c1adaa55cc21ed522dddf14a72413</citedby><cites>FETCH-LOGICAL-c520t-bb2675d4d51b687fa4c669efa0bbdf85d0f6c1adaa55cc21ed522dddf14a72413</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S107476130700338X$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17658278$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fang, Terry C.</creatorcontrib><creatorcontrib>Yashiro-Ohtani, Yumi</creatorcontrib><creatorcontrib>Del Bianco, Cristina</creatorcontrib><creatorcontrib>Knoblock, Dawson M.</creatorcontrib><creatorcontrib>Blacklow, Stephen C.</creatorcontrib><creatorcontrib>Pear, Warren S.</creatorcontrib><title>Notch Directly Regulates Gata3 Expression during T Helper 2 Cell Differentiation</title><title>Immunity (Cambridge, Mass.)</title><addtitle>Immunity</addtitle><description>Notch signaling plays multiple roles to direct diverse decisions regarding cell fate during T cell development. During helper T (Th) cell differentiation, Notch is involved in generating optimal Th2 cell responses. Here, we present data investigating how Notch mediates Th2 cell differentiation. Notch showed a CD4
+ T cell intrinsic role in promoting IL-4 expression that required GATA-3. In the absence of Notch signals,
Gata3 expression was markedly diminished. Introduction of an activated allele of Notch1 into CD4
+ T cells led to the specific and direct upregulation of a developmentally regulated
Gata3 transcript that included the exon 1a sequences. Furthermore, Notch acted in parallel with GATA-3 to synergistically activate IL-4 expression. Together, these data implicate
Gata3 as a direct transcriptional Notch target that acts in concert with Notch signaling to generate optimal Th2 cell responses.</description><subject>Animals</subject><subject>Cell culture</subject><subject>Cell Differentiation - immunology</subject><subject>CELLIMMUNO</subject><subject>Cells, Cultured</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>DNA methylation</subject><subject>Down-Regulation - immunology</subject><subject>GATA3 Transcription Factor - antagonists & inhibitors</subject><subject>GATA3 Transcription Factor - biosynthesis</subject><subject>GATA3 Transcription Factor - genetics</subject><subject>GATA3 Transcription Factor - metabolism</subject><subject>Gene Expression Regulation - immunology</subject><subject>Genetic testing</subject><subject>Lymphocytes</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Mice, Inbred C57BL</subject><subject>Mice, Knockout</subject><subject>Mice, Transgenic</subject><subject>MOLIMMUNO</subject><subject>Receptors, Notch - physiology</subject><subject>Signal Transduction - immunology</subject><subject>T cell receptors</subject><subject>Th2 Cells - cytology</subject><subject>Th2 Cells - immunology</subject><subject>Th2 Cells - metabolism</subject><subject>Transcription factors</subject><issn>1074-7613</issn><issn>1097-4180</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkV9rFDEUxYMotla_gUhA8G3G3Gz-zL4IstZWKFWkPodMcmebZWayJjOl_fbNuotVH-xTAjnn5N7zI-Q1sBoYqPebOgzDPIaaM6ZrJmoGzRNyDGypKwENe7q7a1FpBYsj8iLnDWMg5JI9J0eglWy4bo7Jt8s4uWv6KSR0U39Hv-N67u2EmZ7ZyS7o6e02Yc4hjtTPKYxrekXPsd9iopyusO-Ltesw4TgFOxXZS_Kss33GV4fzhPz4fHq1Oq8uvp59WX28qJzkbKralistvfASWtXozgqn1BI7y9rWd430rFMOrLdWSuc4oJece-87EFZzAYsT8mGfu53bAb0rAyTbm20Kg013Jtpg_n4Zw7VZxxvDGwZSqBLw7hCQ4s8Z82SGkF3ZyI4Y52xUU6oE9bgQllpqpUQRvv1HuIlzGksLBiQTXGqxaIpK7FUuxZwTdr9nBmZ2ZM3G7MmaHVnDhClki-3Nn_s-mA4oHwrB0vpNwGSyCzg69L_YGh_D_3-4B7GIt7g</recordid><startdate>20070701</startdate><enddate>20070701</enddate><creator>Fang, Terry C.</creator><creator>Yashiro-Ohtani, Yumi</creator><creator>Del Bianco, Cristina</creator><creator>Knoblock, Dawson M.</creator><creator>Blacklow, Stephen C.</creator><creator>Pear, Warren S.</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7T5</scope><scope>7T7</scope><scope>7TK</scope><scope>7TM</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>NAPCQ</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20070701</creationdate><title>Notch Directly Regulates Gata3 Expression during T Helper 2 Cell Differentiation</title><author>Fang, Terry C. ; Yashiro-Ohtani, Yumi ; Del Bianco, Cristina ; Knoblock, Dawson M. ; Blacklow, Stephen C. ; Pear, Warren S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c520t-bb2675d4d51b687fa4c669efa0bbdf85d0f6c1adaa55cc21ed522dddf14a72413</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Animals</topic><topic>Cell culture</topic><topic>Cell Differentiation - immunology</topic><topic>CELLIMMUNO</topic><topic>Cells, Cultured</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>DNA methylation</topic><topic>Down-Regulation - immunology</topic><topic>GATA3 Transcription Factor - antagonists & inhibitors</topic><topic>GATA3 Transcription Factor - biosynthesis</topic><topic>GATA3 Transcription Factor - genetics</topic><topic>GATA3 Transcription Factor - metabolism</topic><topic>Gene Expression Regulation - immunology</topic><topic>Genetic testing</topic><topic>Lymphocytes</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Mice, Inbred C57BL</topic><topic>Mice, Knockout</topic><topic>Mice, Transgenic</topic><topic>MOLIMMUNO</topic><topic>Receptors, Notch - physiology</topic><topic>Signal Transduction - immunology</topic><topic>T cell receptors</topic><topic>Th2 Cells - cytology</topic><topic>Th2 Cells - immunology</topic><topic>Th2 Cells - metabolism</topic><topic>Transcription factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fang, Terry C.</creatorcontrib><creatorcontrib>Yashiro-Ohtani, Yumi</creatorcontrib><creatorcontrib>Del Bianco, Cristina</creatorcontrib><creatorcontrib>Knoblock, Dawson M.</creatorcontrib><creatorcontrib>Blacklow, Stephen C.</creatorcontrib><creatorcontrib>Pear, Warren S.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Immunity (Cambridge, Mass.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fang, Terry C.</au><au>Yashiro-Ohtani, Yumi</au><au>Del Bianco, Cristina</au><au>Knoblock, Dawson M.</au><au>Blacklow, Stephen C.</au><au>Pear, Warren S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Notch Directly Regulates Gata3 Expression during T Helper 2 Cell Differentiation</atitle><jtitle>Immunity (Cambridge, Mass.)</jtitle><addtitle>Immunity</addtitle><date>2007-07-01</date><risdate>2007</risdate><volume>27</volume><issue>1</issue><spage>100</spage><epage>110</epage><pages>100-110</pages><issn>1074-7613</issn><eissn>1097-4180</eissn><abstract>Notch signaling plays multiple roles to direct diverse decisions regarding cell fate during T cell development. During helper T (Th) cell differentiation, Notch is involved in generating optimal Th2 cell responses. Here, we present data investigating how Notch mediates Th2 cell differentiation. Notch showed a CD4
+ T cell intrinsic role in promoting IL-4 expression that required GATA-3. In the absence of Notch signals,
Gata3 expression was markedly diminished. Introduction of an activated allele of Notch1 into CD4
+ T cells led to the specific and direct upregulation of a developmentally regulated
Gata3 transcript that included the exon 1a sequences. Furthermore, Notch acted in parallel with GATA-3 to synergistically activate IL-4 expression. Together, these data implicate
Gata3 as a direct transcriptional Notch target that acts in concert with Notch signaling to generate optimal Th2 cell responses.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>17658278</pmid><doi>10.1016/j.immuni.2007.04.018</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Cell culture Cell Differentiation - immunology CELLIMMUNO Cells, Cultured Deoxyribonucleic acid DNA DNA methylation Down-Regulation - immunology GATA3 Transcription Factor - antagonists & inhibitors GATA3 Transcription Factor - biosynthesis GATA3 Transcription Factor - genetics GATA3 Transcription Factor - metabolism Gene Expression Regulation - immunology Genetic testing Lymphocytes Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Knockout Mice, Transgenic MOLIMMUNO Receptors, Notch - physiology Signal Transduction - immunology T cell receptors Th2 Cells - cytology Th2 Cells - immunology Th2 Cells - metabolism Transcription factors |
| title | Notch Directly Regulates Gata3 Expression during T Helper 2 Cell Differentiation |
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