Complement Factor H Binds at Two Independent Sites to C-reactive Protein in Acute Phase Concentrations

Factor H (FH) regulates the activation of C3b in the alternative complement pathway, both in serum and at host cell surfaces. It is composed of 20 short complement regulator (SCR) domains. The Y402H polymorphism in FH is a risk factor for age-related macular degeneration. C-reactive protein (CRP) is...

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Veröffentlicht in:	The Journal of biological chemistry 2010-01, Vol.285 (2), p.1053-1065
Hauptverfasser:	Okemefuna, Azubuike I., Nan, Ruodan, Miller, Ami, Gor, Jayesh, Perkins, Stephen J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute-Phase Reaction - genetics Acute-Phase Reaction - metabolism Amino Acid Substitution - physiology Binding Sites - genetics C-Reactive Protein - chemistry C-Reactive Protein - genetics C-Reactive Protein - metabolism Calcium - chemistry Calcium - metabolism Complement C3b - genetics Complement C3b - metabolism Complement Factor H - chemistry Complement Factor H - genetics Complement Factor H - metabolism Humans Macular Degeneration - genetics Macular Degeneration - metabolism Polymorphism, Genetic Protein Binding - genetics Protein Structure and Folding Protein Structure, Quaternary - genetics Risk Factors Sodium Chloride - chemistry Sodium Chloride - metabolism
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