Reduced Vessel Elasticity Alters Cardiovascular Structure and Function in Newborn Mice

Elastic blood vessels provide capacitance and pulse-wave dampening, which are critically important in a pulsatile circulatory system. By studying newborn mice with reduced (Eln) or no (Eln) elastin, we determined the effects of altered vessel elasticity on cardiovascular development and function. El...

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Veröffentlicht in:	Circulation research 2009-05, Vol.104 (10), p.1217-1224
Hauptverfasser:	Wagenseil, Jessica E, Ciliberto, Chris H, Knutsen, Russell H, Levy, Marilyn A, Kovacs, Attila, Mecham, Robert P
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn - physiology Aorta - cytology Aorta - physiology Arteries - cytology Arteries - physiology Biological and medical sciences Cardiovascular Physiological Phenomena Cardiovascular System - anatomy & histology Cardiovascular System - cytology Cardiovascular System - metabolism Cell Proliferation Elasticity - physiology Elastin - genetics Elastin - metabolism Fundamental and applied biological sciences. Psychology Mice Mice, Inbred C57BL Mice, Knockout Muscle, Smooth, Vascular - anatomy & histology Muscle, Smooth, Vascular - cytology Muscle, Smooth, Vascular - metabolism Vasodilation - physiology Ventricular Function, Left - physiology Vertebrates: cardiovascular system
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