Energetic signatures of single base bulges: thermodynamic consequences and biological implications

DNA bulges are biologically consequential defects that can arise from template-primer misalignments during replication and pose challenges to the cellular DNA repair machinery. Calorimetric and spectroscopic characterizations of defect-containing duplexes reveal systematic patterns of sequence-conte...

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Veröffentlicht in:	Nucleic acids research 2010-01, Vol.38 (1), p.97-116
Hauptverfasser:	Minetti, Conceição A.S.A, Remeta, David P, Dickstein, Rian, Breslauer, Kenneth J
Format:	Artikel
Sprache:	eng
Schlagworte:	Calorimetry, Differential Scanning DNA - chemistry DNA Repair DNA Replication Genome Integrity, Repair and Models, Genetic Nucleic Acid Conformation Purines - chemistry Pyrimidines - chemistry Thermodynamics
Online-Zugang:	Volltext
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