Virulence Locus of Pseudomonas aeruginosa Encodes a Protein Secretion Apparatus
Bacterial pathogens frequently use protein secretion to mediate interactions with their hosts. Here we found that a virulence locus (HSI-I) of Pseudomonas aeruginosa encodes a protein secretion apparatus. The apparatus assembled in discrete subcellular locations and exported Hcp1, a hexameric protei...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 2006-06, Vol.312 (5779), p.1526-1530 |
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| creator | Mougous, Joseph D Cuff, Marianne E Raunser, Stefan Shen, Aimee Zhou, Min Gifford, Casey A Goodman, Andrew L Joachimiak, Grazyna Ordoñez, Claudia L Lory, Stephen Walz, Thomas Joachimiak, Andrzej Mekalanos, John J |
| description | Bacterial pathogens frequently use protein secretion to mediate interactions with their hosts. Here we found that a virulence locus (HSI-I) of Pseudomonas aeruginosa encodes a protein secretion apparatus. The apparatus assembled in discrete subcellular locations and exported Hcp1, a hexameric protein that forms rings with a 40 angstrom internal diameter. Regulatory patterns of HSI-I suggested that the apparatus functions during chronic infections. We detected Hcp1 in pulmonary secretions of cystic fibrosis (CF) patients and Hcp1-specific antibodies in their sera. Thus, HSI-I likely contributes to the pathogenesis of P. aeruginosa in CF patients. HSI-I-related loci are widely distributed among bacterial pathogens and may play a general role in mediating host interactions. |
| doi_str_mv | 10.1126/science.1128393 |
| format | Article |
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(ANL), Argonne, IL (United States)</creatorcontrib><description>Bacterial pathogens frequently use protein secretion to mediate interactions with their hosts. Here we found that a virulence locus (HSI-I) of Pseudomonas aeruginosa encodes a protein secretion apparatus. The apparatus assembled in discrete subcellular locations and exported Hcp1, a hexameric protein that forms rings with a 40 angstrom internal diameter. Regulatory patterns of HSI-I suggested that the apparatus functions during chronic infections. We detected Hcp1 in pulmonary secretions of cystic fibrosis (CF) patients and Hcp1-specific antibodies in their sera. Thus, HSI-I likely contributes to the pathogenesis of P. aeruginosa in CF patients. HSI-I-related loci are widely distributed among bacterial pathogens and may play a general role in mediating host interactions.</description><identifier>ISSN: 0036-8075</identifier><identifier>ISSN: 0193-4511</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.1128393</identifier><identifier>PMID: 16763151</identifier><identifier>CODEN: SCIEAS</identifier><language>eng</language><publisher>Washington, DC: American Association for the Advancement of Science</publisher><subject>Animals ; Bacteria ; Bacterial proteins ; Bacterial Proteins - genetics ; Bacterial Proteins - metabolism ; Bacterial Proteins - physiology ; Bacteriology ; BASIC BIOLOGICAL SCIENCES ; Biological and medical sciences ; Crystallography, X-Ray ; Cystic fibrosis ; Cystic Fibrosis - complications ; Cystic Fibrosis - microbiology ; Fundamental and applied biological sciences. Psychology ; Gene expression regulation ; Genetic loci ; Heat tolerance ; Humans ; Infections ; Microbiology ; Models, Molecular ; Open reading frames ; Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains ; Pathogens ; Protein Conformation ; Protein secretion ; PROTEINS ; PSEUDOMONAS ; Pseudomonas aeruginosa ; Pseudomonas aeruginosa - genetics ; Pseudomonas aeruginosa - pathogenicity ; Pseudomonas Infections - complications ; Pseudomonas Infections - microbiology ; Rats ; Recombinant Fusion Proteins ; SECRETION ; Sequence Alignment ; Sputum ; VIRULENCE ; Virulence - genetics</subject><ispartof>Science (American Association for the Advancement of Science), 2006-06, Vol.312 (5779), p.1526-1530</ispartof><rights>Copyright 2006 American Association for the Advancement of Science</rights><rights>2006 INIST-CNRS</rights><rights>Copyright American Association for the Advancement of Science Jun 9, 2006</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c658t-617a754a40b08f65c4f00024274a53a8cd9103c0972195f2881b357a548f5df43</citedby><cites>FETCH-LOGICAL-c658t-617a754a40b08f65c4f00024274a53a8cd9103c0972195f2881b357a548f5df43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/3846320$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/3846320$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,780,784,803,885,2884,2885,27924,27925,58017,58250</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17929398$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16763151$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/928675$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Mougous, Joseph D</creatorcontrib><creatorcontrib>Cuff, Marianne E</creatorcontrib><creatorcontrib>Raunser, Stefan</creatorcontrib><creatorcontrib>Shen, Aimee</creatorcontrib><creatorcontrib>Zhou, Min</creatorcontrib><creatorcontrib>Gifford, Casey A</creatorcontrib><creatorcontrib>Goodman, Andrew L</creatorcontrib><creatorcontrib>Joachimiak, Grazyna</creatorcontrib><creatorcontrib>Ordoñez, Claudia L</creatorcontrib><creatorcontrib>Lory, Stephen</creatorcontrib><creatorcontrib>Walz, Thomas</creatorcontrib><creatorcontrib>Joachimiak, Andrzej</creatorcontrib><creatorcontrib>Mekalanos, John J</creatorcontrib><creatorcontrib>Argonne National Lab. (ANL), Argonne, IL (United States)</creatorcontrib><title>Virulence Locus of Pseudomonas aeruginosa Encodes a Protein Secretion Apparatus</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>Bacterial pathogens frequently use protein secretion to mediate interactions with their hosts. Here we found that a virulence locus (HSI-I) of Pseudomonas aeruginosa encodes a protein secretion apparatus. The apparatus assembled in discrete subcellular locations and exported Hcp1, a hexameric protein that forms rings with a 40 angstrom internal diameter. Regulatory patterns of HSI-I suggested that the apparatus functions during chronic infections. We detected Hcp1 in pulmonary secretions of cystic fibrosis (CF) patients and Hcp1-specific antibodies in their sera. Thus, HSI-I likely contributes to the pathogenesis of P. aeruginosa in CF patients. HSI-I-related loci are widely distributed among bacterial pathogens and may play a general role in mediating host interactions.</description><subject>Animals</subject><subject>Bacteria</subject><subject>Bacterial proteins</subject><subject>Bacterial Proteins - genetics</subject><subject>Bacterial Proteins - metabolism</subject><subject>Bacterial Proteins - physiology</subject><subject>Bacteriology</subject><subject>BASIC BIOLOGICAL SCIENCES</subject><subject>Biological and medical sciences</subject><subject>Crystallography, X-Ray</subject><subject>Cystic fibrosis</subject><subject>Cystic Fibrosis - complications</subject><subject>Cystic Fibrosis - microbiology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene expression regulation</subject><subject>Genetic loci</subject><subject>Heat tolerance</subject><subject>Humans</subject><subject>Infections</subject><subject>Microbiology</subject><subject>Models, Molecular</subject><subject>Open reading frames</subject><subject>Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains</subject><subject>Pathogens</subject><subject>Protein Conformation</subject><subject>Protein secretion</subject><subject>PROTEINS</subject><subject>PSEUDOMONAS</subject><subject>Pseudomonas aeruginosa</subject><subject>Pseudomonas aeruginosa - genetics</subject><subject>Pseudomonas aeruginosa - pathogenicity</subject><subject>Pseudomonas Infections - complications</subject><subject>Pseudomonas Infections - microbiology</subject><subject>Rats</subject><subject>Recombinant Fusion Proteins</subject><subject>SECRETION</subject><subject>Sequence Alignment</subject><subject>Sputum</subject><subject>VIRULENCE</subject><subject>Virulence - genetics</subject><issn>0036-8075</issn><issn>0193-4511</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFks1rFDEYxoModl09exEdBb2NfZNMvi5CKfUDFlqo9Rqymcw2y2yyJjOC_70ZZmjVS08heX553g8ehF5i-Igx4afZehesmy6SKvoIrTAoVisC9DFaAVBeSxDsBD3LeQ9QNEWfohPMBaeY4RW6_OHT2E8e1SbaMVexq66yG9t4iMHkyrg07nyI2VQXwcbWlafqKsXB-VBdO5vc4GOozo5Hk8ww5ufoSWf67F4s5xrdfL74fv613lx--XZ-tqktZ3KoORZGsMY0sAXZcWabrnRHGiIaw6iRtlUYqAUlCFasI1LiLWXCsEZ2rO0aukafZt_juD241rowJNPrY_IHk37raLz-Vwn-Vu_iL00kQBm_GLydDWIevC57HJy9tTEEZwetiOSCFebDUiTFn6PLgz74bF3fm-DimDWXwIni6kGQSIwx5fRBEAusqABZwHf_gfs4plBWqklxIpKRCTqdIZtizsl1d_Nj0FM-9JIPveSj_Hj999ru-SUQBXi_ACZb03fJBOvzPScUUVRNpV_N3D4PMd3pVDaclvCt0ZtZ7kzUZpeKxc01AUwBg1AcOP0Dy9TVoA</recordid><startdate>20060609</startdate><enddate>20060609</enddate><creator>Mougous, Joseph D</creator><creator>Cuff, Marianne E</creator><creator>Raunser, Stefan</creator><creator>Shen, Aimee</creator><creator>Zhou, Min</creator><creator>Gifford, Casey A</creator><creator>Goodman, Andrew L</creator><creator>Joachimiak, Grazyna</creator><creator>Ordoñez, Claudia L</creator><creator>Lory, Stephen</creator><creator>Walz, Thomas</creator><creator>Joachimiak, Andrzej</creator><creator>Mekalanos, John J</creator><general>American Association for the Advancement of Science</general><general>The American Association for the Advancement of Science</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QQ</scope><scope>7QR</scope><scope>7SC</scope><scope>7SE</scope><scope>7SN</scope><scope>7SP</scope><scope>7SR</scope><scope>7SS</scope><scope>7T7</scope><scope>7TA</scope><scope>7TB</scope><scope>7TK</scope><scope>7TM</scope><scope>7U5</scope><scope>7U9</scope><scope>8BQ</scope><scope>8FD</scope><scope>C1K</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>H94</scope><scope>JG9</scope><scope>JQ2</scope><scope>K9.</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>OTOTI</scope><scope>5PM</scope></search><sort><creationdate>20060609</creationdate><title>Virulence Locus of Pseudomonas aeruginosa Encodes a Protein Secretion Apparatus</title><author>Mougous, Joseph D ; Cuff, Marianne E ; Raunser, Stefan ; Shen, Aimee ; Zhou, Min ; Gifford, Casey A ; Goodman, Andrew L ; Joachimiak, Grazyna ; Ordoñez, Claudia L ; Lory, Stephen ; Walz, Thomas ; Joachimiak, Andrzej ; Mekalanos, John J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c658t-617a754a40b08f65c4f00024274a53a8cd9103c0972195f2881b357a548f5df43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Animals</topic><topic>Bacteria</topic><topic>Bacterial proteins</topic><topic>Bacterial Proteins - genetics</topic><topic>Bacterial Proteins - metabolism</topic><topic>Bacterial Proteins - physiology</topic><topic>Bacteriology</topic><topic>BASIC BIOLOGICAL SCIENCES</topic><topic>Biological and medical sciences</topic><topic>Crystallography, X-Ray</topic><topic>Cystic fibrosis</topic><topic>Cystic Fibrosis - complications</topic><topic>Cystic Fibrosis - microbiology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene expression regulation</topic><topic>Genetic loci</topic><topic>Heat tolerance</topic><topic>Humans</topic><topic>Infections</topic><topic>Microbiology</topic><topic>Models, Molecular</topic><topic>Open reading frames</topic><topic>Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains</topic><topic>Pathogens</topic><topic>Protein Conformation</topic><topic>Protein secretion</topic><topic>PROTEINS</topic><topic>PSEUDOMONAS</topic><topic>Pseudomonas aeruginosa</topic><topic>Pseudomonas aeruginosa - genetics</topic><topic>Pseudomonas aeruginosa - pathogenicity</topic><topic>Pseudomonas Infections - complications</topic><topic>Pseudomonas Infections - microbiology</topic><topic>Rats</topic><topic>Recombinant Fusion Proteins</topic><topic>SECRETION</topic><topic>Sequence Alignment</topic><topic>Sputum</topic><topic>VIRULENCE</topic><topic>Virulence - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mougous, Joseph D</creatorcontrib><creatorcontrib>Cuff, Marianne E</creatorcontrib><creatorcontrib>Raunser, Stefan</creatorcontrib><creatorcontrib>Shen, Aimee</creatorcontrib><creatorcontrib>Zhou, Min</creatorcontrib><creatorcontrib>Gifford, Casey A</creatorcontrib><creatorcontrib>Goodman, Andrew L</creatorcontrib><creatorcontrib>Joachimiak, Grazyna</creatorcontrib><creatorcontrib>Ordoñez, Claudia L</creatorcontrib><creatorcontrib>Lory, Stephen</creatorcontrib><creatorcontrib>Walz, Thomas</creatorcontrib><creatorcontrib>Joachimiak, Andrzej</creatorcontrib><creatorcontrib>Mekalanos, John J</creatorcontrib><creatorcontrib>Argonne National Lab. 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(ANL), Argonne, IL (United States)</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Virulence Locus of Pseudomonas aeruginosa Encodes a Protein Secretion Apparatus</atitle><jtitle>Science (American Association for the Advancement of Science)</jtitle><addtitle>Science</addtitle><date>2006-06-09</date><risdate>2006</risdate><volume>312</volume><issue>5779</issue><spage>1526</spage><epage>1530</epage><pages>1526-1530</pages><issn>0036-8075</issn><issn>0193-4511</issn><eissn>1095-9203</eissn><coden>SCIEAS</coden><abstract>Bacterial pathogens frequently use protein secretion to mediate interactions with their hosts. Here we found that a virulence locus (HSI-I) of Pseudomonas aeruginosa encodes a protein secretion apparatus. The apparatus assembled in discrete subcellular locations and exported Hcp1, a hexameric protein that forms rings with a 40 angstrom internal diameter. Regulatory patterns of HSI-I suggested that the apparatus functions during chronic infections. We detected Hcp1 in pulmonary secretions of cystic fibrosis (CF) patients and Hcp1-specific antibodies in their sera. Thus, HSI-I likely contributes to the pathogenesis of P. aeruginosa in CF patients. HSI-I-related loci are widely distributed among bacterial pathogens and may play a general role in mediating host interactions.</abstract><cop>Washington, DC</cop><pub>American Association for the Advancement of Science</pub><pmid>16763151</pmid><doi>10.1126/science.1128393</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 2006-06, Vol.312 (5779), p.1526-1530 |
| issn | 0036-8075 0193-4511 1095-9203 |
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| source | MEDLINE; JSTOR Archive Collection A-Z Listing; American Association for the Advancement of Science |
| subjects | Animals Bacteria Bacterial proteins Bacterial Proteins - genetics Bacterial Proteins - metabolism Bacterial Proteins - physiology Bacteriology BASIC BIOLOGICAL SCIENCES Biological and medical sciences Crystallography, X-Ray Cystic fibrosis Cystic Fibrosis - complications Cystic Fibrosis - microbiology Fundamental and applied biological sciences. Psychology Gene expression regulation Genetic loci Heat tolerance Humans Infections Microbiology Models, Molecular Open reading frames Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains Pathogens Protein Conformation Protein secretion PROTEINS PSEUDOMONAS Pseudomonas aeruginosa Pseudomonas aeruginosa - genetics Pseudomonas aeruginosa - pathogenicity Pseudomonas Infections - complications Pseudomonas Infections - microbiology Rats Recombinant Fusion Proteins SECRETION Sequence Alignment Sputum VIRULENCE Virulence - genetics |
| title | Virulence Locus of Pseudomonas aeruginosa Encodes a Protein Secretion Apparatus |
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