Structural abnormality of the substantia nigra in children with attention-deficit hyperactivity disorder
Background Structural abnormality of the substantia nigra can be detected by transcranial sonography in neuropsychiatric disorders such as Parkinson disease and restless legs syndrome. We investigated echogenicity of the substantia nigra as a potential structural marker for dysfunction of the nigros...
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| Veröffentlicht in: | Journal of psychiatry & neuroscience 2010, Vol.35 (1), p.55-58 |
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| creator | Romanos, Marcel, MD Weise, David, MD Schliesser, Mira Schecklmann, Martin, PhD Löffler, Julia Warnke, Andreas, MD, PhD Gerlach, Manfred, PhD Classen, Joseph, MD Mehler-Wex, Claudia, MD |
| description | Background Structural abnormality of the substantia nigra can be detected by transcranial sonography in neuropsychiatric disorders such as Parkinson disease and restless legs syndrome. We investigated echogenicity of the substantia nigra as a potential structural marker for dysfunction of the nigrostriatal dopamine system in children with attention-deficit hyperactivity disorder (ADHD). Methods We used a blinded design and determined echogenicity of the substantia nigra by use of transcranial sonography in 22 children with ADHD and 22 healthy controls matched for age and sex. Results The echogenic substantia nigra area was significantly larger in ADHD patients than in healthy controls ( F1,42 = 9.298, p = 0.004, effect size = 0.92). We found no effects of age or sex. Limitations Owing to a lack of dimensional assessment, we could not analyze the correlation between echogenicity and clinical symptoms. Conclusion Our results support the hypothesis that the nigrostriatal dopaminergic system is abnormal in children with ADHD. |
| doi_str_mv | 10.1503/jpn.090044 |
| format | Article |
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We investigated echogenicity of the substantia nigra as a potential structural marker for dysfunction of the nigrostriatal dopamine system in children with attention-deficit hyperactivity disorder (ADHD). Methods We used a blinded design and determined echogenicity of the substantia nigra by use of transcranial sonography in 22 children with ADHD and 22 healthy controls matched for age and sex. Results The echogenic substantia nigra area was significantly larger in ADHD patients than in healthy controls ( F1,42 = 9.298, p = 0.004, effect size = 0.92). We found no effects of age or sex. Limitations Owing to a lack of dimensional assessment, we could not analyze the correlation between echogenicity and clinical symptoms. Conclusion Our results support the hypothesis that the nigrostriatal dopaminergic system is abnormal in children with ADHD.</description><identifier>ISSN: 1180-4882</identifier><identifier>EISSN: 1488-2434</identifier><identifier>DOI: 10.1503/jpn.090044</identifier><identifier>PMID: 20040247</identifier><identifier>CODEN: JPNEEF</identifier><language>eng</language><publisher>Ottawa, ON: Canadian Medical Association</publisher><subject>Abnormalities ; Adolescent ; Age Factors ; Analysis of Variance ; Attention Deficit Disorder with Hyperactivity - diagnostic imaging ; Attention Deficit Disorder with Hyperactivity - epidemiology ; Attention Deficit Disorder with Hyperactivity - pathology ; Attention deficit hyperactivity disorder ; Biological and medical sciences ; Brain ; Brain stem ; Brief Report ; Child ; Child & adolescent psychiatry ; Comorbidity ; Female ; Fundamental and applied biological sciences. Psychology ; Humans ; Male ; Medical Education ; Medical sciences ; Organ Size ; Physiological aspects ; Psychiatry ; Psychoanalysis ; Psychology. Psychoanalysis. Psychiatry ; Psychology. Psychophysiology ; Psychopathology. Psychiatry ; Risk factors ; Sex Factors ; Studies ; Substantia Nigra - abnormalities ; Substantia Nigra - diagnostic imaging ; Substantia Nigra - pathology ; Ultrasonography, Doppler, Transcranial</subject><ispartof>Journal of psychiatry & neuroscience, 2010, Vol.35 (1), p.55-58</ispartof><rights>Canadian Medical Association</rights><rights>2015 INIST-CNRS</rights><rights>COPYRIGHT 2010 Joule Inc.</rights><rights>Copyright Canadian Medical Association Jan 2010</rights><rights>2009 Canadian Medical Association</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c720t-bb457700dde5d4014830b6b3ef806b62daeeb00079094ca983162a6abf2e59a13</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2799505/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2799505/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,4009,27902,27903,27904,53769,53771</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22484138$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20040247$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Romanos, Marcel, MD</creatorcontrib><creatorcontrib>Weise, David, MD</creatorcontrib><creatorcontrib>Schliesser, Mira</creatorcontrib><creatorcontrib>Schecklmann, Martin, PhD</creatorcontrib><creatorcontrib>Löffler, Julia</creatorcontrib><creatorcontrib>Warnke, Andreas, MD, PhD</creatorcontrib><creatorcontrib>Gerlach, Manfred, PhD</creatorcontrib><creatorcontrib>Classen, Joseph, MD</creatorcontrib><creatorcontrib>Mehler-Wex, Claudia, MD</creatorcontrib><title>Structural abnormality of the substantia nigra in children with attention-deficit hyperactivity disorder</title><title>Journal of psychiatry & neuroscience</title><addtitle>J Psychiatry Neurosci</addtitle><description>Background Structural abnormality of the substantia nigra can be detected by transcranial sonography in neuropsychiatric disorders such as Parkinson disease and restless legs syndrome. We investigated echogenicity of the substantia nigra as a potential structural marker for dysfunction of the nigrostriatal dopamine system in children with attention-deficit hyperactivity disorder (ADHD). Methods We used a blinded design and determined echogenicity of the substantia nigra by use of transcranial sonography in 22 children with ADHD and 22 healthy controls matched for age and sex. Results The echogenic substantia nigra area was significantly larger in ADHD patients than in healthy controls ( F1,42 = 9.298, p = 0.004, effect size = 0.92). We found no effects of age or sex. Limitations Owing to a lack of dimensional assessment, we could not analyze the correlation between echogenicity and clinical symptoms. Conclusion Our results support the hypothesis that the nigrostriatal dopaminergic system is abnormal in children with ADHD.</description><subject>Abnormalities</subject><subject>Adolescent</subject><subject>Age Factors</subject><subject>Analysis of Variance</subject><subject>Attention Deficit Disorder with Hyperactivity - diagnostic imaging</subject><subject>Attention Deficit Disorder with Hyperactivity - epidemiology</subject><subject>Attention Deficit Disorder with Hyperactivity - pathology</subject><subject>Attention deficit hyperactivity disorder</subject><subject>Biological and medical sciences</subject><subject>Brain</subject><subject>Brain stem</subject><subject>Brief Report</subject><subject>Child</subject><subject>Child & adolescent psychiatry</subject><subject>Comorbidity</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Male</subject><subject>Medical Education</subject><subject>Medical sciences</subject><subject>Organ Size</subject><subject>Physiological aspects</subject><subject>Psychiatry</subject><subject>Psychoanalysis</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychology. Psychophysiology</subject><subject>Psychopathology. Psychiatry</subject><subject>Risk factors</subject><subject>Sex Factors</subject><subject>Studies</subject><subject>Substantia Nigra - abnormalities</subject><subject>Substantia Nigra - diagnostic imaging</subject><subject>Substantia Nigra - pathology</subject><subject>Ultrasonography, Doppler, Transcranial</subject><issn>1180-4882</issn><issn>1488-2434</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqV01tv0zAUB_AIgdgYvPABULQJEEgptuPcXpCmicukCSQKz5bjnDQurt3ZzqDfnhN1bC3qC8pDLv75JCf-O0meUzKjBcnfLdd2RhpCOH-QHFNe1xnjOX-I17QmGd6zo-RJCEtCCCO0eJwcMcSE8eo4GebRjyqOXppUttb5lTQ6blLXp3GANIxtiNJGLVOrF16m2qZq0KbzYNNfOg6pjBFw3Nmsg14rHdNhswYvVdQ3U6FOB-c78E-TR700AZ7dnk-SHx8_fL_4nF19_XR5cX6VqYqRmLUtL6qKkK6DouMEu8lJW7Y59DUp25J1EqDFRqqGNFzJps5pyWQp255B0UianyTvt3XXY7uCTuHHYW9i7fVK-o1wUov9EasHsXA3glVNU5ACC7y-LeDd9QghipUOCoyRFtwYRJVzRivOKpSn_8ilG73F7gQK1tSsnNDZFi2kAaFt7_CtaiopzhktKtoUDUeVHVALsPgnjbP4Z_Hxnj894NVaX4tdNDuA8OhgpdXBqm_2JqCJ8Dsu5BiCuJx_-w_7Zd--2rEDSBOH4Mw4xSbsw7dbqLwLwUN_t26UiCnrArMutllH_GJ3pe_o33AjeHkLZFDS9F5apcO9Y7zmNK_vIwOYyxsNXiijrcYpP2ED4W5RqQhMEDGfttW0qygppiSW-R8sAhhX</recordid><startdate>2010</startdate><enddate>2010</enddate><creator>Romanos, Marcel, MD</creator><creator>Weise, David, MD</creator><creator>Schliesser, Mira</creator><creator>Schecklmann, Martin, PhD</creator><creator>Löffler, Julia</creator><creator>Warnke, Andreas, MD, PhD</creator><creator>Gerlach, Manfred, PhD</creator><creator>Classen, Joseph, MD</creator><creator>Mehler-Wex, Claudia, MD</creator><general>Canadian Medical Association</general><general>Joule Inc</general><general>CMA Impact, Inc</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>ISN</scope><scope>ISR</scope><scope>3V.</scope><scope>4T-</scope><scope>4U-</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8FQ</scope><scope>8FV</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M3G</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>2010</creationdate><title>Structural abnormality of the substantia nigra in children with attention-deficit hyperactivity disorder</title><author>Romanos, Marcel, MD ; Weise, David, MD ; Schliesser, Mira ; Schecklmann, Martin, PhD ; Löffler, Julia ; Warnke, Andreas, MD, PhD ; Gerlach, Manfred, PhD ; Classen, Joseph, MD ; Mehler-Wex, Claudia, MD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c720t-bb457700dde5d4014830b6b3ef806b62daeeb00079094ca983162a6abf2e59a13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Abnormalities</topic><topic>Adolescent</topic><topic>Age Factors</topic><topic>Analysis of Variance</topic><topic>Attention Deficit Disorder with Hyperactivity - diagnostic imaging</topic><topic>Attention Deficit Disorder with Hyperactivity - epidemiology</topic><topic>Attention Deficit Disorder with Hyperactivity - pathology</topic><topic>Attention deficit hyperactivity disorder</topic><topic>Biological and medical sciences</topic><topic>Brain</topic><topic>Brain stem</topic><topic>Brief Report</topic><topic>Child</topic><topic>Child & adolescent psychiatry</topic><topic>Comorbidity</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. 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We investigated echogenicity of the substantia nigra as a potential structural marker for dysfunction of the nigrostriatal dopamine system in children with attention-deficit hyperactivity disorder (ADHD). Methods We used a blinded design and determined echogenicity of the substantia nigra by use of transcranial sonography in 22 children with ADHD and 22 healthy controls matched for age and sex. Results The echogenic substantia nigra area was significantly larger in ADHD patients than in healthy controls ( F1,42 = 9.298, p = 0.004, effect size = 0.92). We found no effects of age or sex. Limitations Owing to a lack of dimensional assessment, we could not analyze the correlation between echogenicity and clinical symptoms. Conclusion Our results support the hypothesis that the nigrostriatal dopaminergic system is abnormal in children with ADHD.</abstract><cop>Ottawa, ON</cop><pub>Canadian Medical Association</pub><pmid>20040247</pmid><doi>10.1503/jpn.090044</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Abnormalities Adolescent Age Factors Analysis of Variance Attention Deficit Disorder with Hyperactivity - diagnostic imaging Attention Deficit Disorder with Hyperactivity - epidemiology Attention Deficit Disorder with Hyperactivity - pathology Attention deficit hyperactivity disorder Biological and medical sciences Brain Brain stem Brief Report Child Child & adolescent psychiatry Comorbidity Female Fundamental and applied biological sciences. Psychology Humans Male Medical Education Medical sciences Organ Size Physiological aspects Psychiatry Psychoanalysis Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Psychopathology. Psychiatry Risk factors Sex Factors Studies Substantia Nigra - abnormalities Substantia Nigra - diagnostic imaging Substantia Nigra - pathology Ultrasonography, Doppler, Transcranial |
| title | Structural abnormality of the substantia nigra in children with attention-deficit hyperactivity disorder |
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