Well-water consumption and Parkinson's disease in rural California
Investigators have hypothesized that consuming pesticide-contaminated well water plays a role in Parkinson's disease (PD), and several previous epidemiologic studies support this hypothesis. We investigated whether consuming water from private wells located in areas with documented historical p...
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| Veröffentlicht in: | Environmental health perspectives 2009-12, Vol.117 (12), p.1912-1918 |
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| creator | Gatto, Nicole M Cockburn, Myles Bronstein, Jeff Manthripragada, Angelika D Ritz, Beate |
| description | Investigators have hypothesized that consuming pesticide-contaminated well water plays a role in Parkinson's disease (PD), and several previous epidemiologic studies support this hypothesis.
We investigated whether consuming water from private wells located in areas with documented historical pesticide use was associated with an increased risk of PD.
We employed a geographic information system (GIS)-based model to estimate potential well-water contamination from agricultural pesticides among 368 cases and 341 population controls enrolled in the Parkinson's Environment and Genes Study (PEG). We separately examined 6 pesticides (diazinon, chlorpyrifos, propargite, paraquat, dimethoate, and methomyl) from among 26 chemicals selected for their potential to pollute groundwater or for their interest in PD, and because at least 10% of our population was exposed to them.
Cases were more likely to have consumed private well water and to have consumed it on average 4.3 years longer than controls (p = 0.02). High levels of possible well-water contamination with methomyl [odds ratio (OR) = 1.67; 95% confidence interval (CI), 1.00-2.78]), chlorpyrifos (OR = 1.87; 95% CI, 1.05-3.31), and propargite (OR = 1.92; 95% CI, 1.15-3.20) resulted in approximately 70-90% increases in relative risk of PD. Adjusting for ambient pesticide exposures only slightly attenuated these increases. Exposure to a higher number of water-soluble pesticides and organophosphate pesticides also increased the relative risk of PD.
Our study, the first to use agricultural pesticide application records, adds evidence that consuming well water presumably contaminated with pesticides may play a role in the etiology of PD. |
| doi_str_mv | 10.1289/ehp.0900852 |
| format | Article |
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We investigated whether consuming water from private wells located in areas with documented historical pesticide use was associated with an increased risk of PD.
We employed a geographic information system (GIS)-based model to estimate potential well-water contamination from agricultural pesticides among 368 cases and 341 population controls enrolled in the Parkinson's Environment and Genes Study (PEG). We separately examined 6 pesticides (diazinon, chlorpyrifos, propargite, paraquat, dimethoate, and methomyl) from among 26 chemicals selected for their potential to pollute groundwater or for their interest in PD, and because at least 10% of our population was exposed to them.
Cases were more likely to have consumed private well water and to have consumed it on average 4.3 years longer than controls (p = 0.02). High levels of possible well-water contamination with methomyl [odds ratio (OR) = 1.67; 95% confidence interval (CI), 1.00-2.78]), chlorpyrifos (OR = 1.87; 95% CI, 1.05-3.31), and propargite (OR = 1.92; 95% CI, 1.15-3.20) resulted in approximately 70-90% increases in relative risk of PD. Adjusting for ambient pesticide exposures only slightly attenuated these increases. Exposure to a higher number of water-soluble pesticides and organophosphate pesticides also increased the relative risk of PD.
Our study, the first to use agricultural pesticide application records, adds evidence that consuming well water presumably contaminated with pesticides may play a role in the etiology of PD.</description><identifier>ISSN: 0091-6765</identifier><identifier>EISSN: 1552-9924</identifier><identifier>DOI: 10.1289/ehp.0900852</identifier><identifier>PMID: 20049211</identifier><language>eng</language><publisher>United States: National Institute of Environmental Health Sciences</publisher><subject>Adult ; Aged ; Agricultural chemicals ; Chlorpyrifos ; Consumption ; Contamination ; Exposure ; Female ; Geographic information systems ; Health aspects ; Herbicides ; Humans ; Male ; Middle Aged ; Parkinson Disease - etiology ; Parkinson's disease ; Pesticides ; Pesticides - toxicity ; Risk ; Risk factors ; Rural Health ; Water Pollutants, Chemical - toxicity ; Water Supply - analysis ; Well waters</subject><ispartof>Environmental health perspectives, 2009-12, Vol.117 (12), p.1912-1918</ispartof><rights>COPYRIGHT 2009 National Institute of Environmental Health Sciences</rights><rights>Copyright National Institute of Environmental Health Sciences Dec 2009</rights><rights>2009</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c680t-f15184d6c35af961786faf80dbaa378c71d3f5efc732a6c43f9d8a012c8daf653</citedby><cites>FETCH-LOGICAL-c680t-f15184d6c35af961786faf80dbaa378c71d3f5efc732a6c43f9d8a012c8daf653</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2799466/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2799466/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20049211$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gatto, Nicole M</creatorcontrib><creatorcontrib>Cockburn, Myles</creatorcontrib><creatorcontrib>Bronstein, Jeff</creatorcontrib><creatorcontrib>Manthripragada, Angelika D</creatorcontrib><creatorcontrib>Ritz, Beate</creatorcontrib><title>Well-water consumption and Parkinson's disease in rural California</title><title>Environmental health perspectives</title><addtitle>Environ Health Perspect</addtitle><description>Investigators have hypothesized that consuming pesticide-contaminated well water plays a role in Parkinson's disease (PD), and several previous epidemiologic studies support this hypothesis.
We investigated whether consuming water from private wells located in areas with documented historical pesticide use was associated with an increased risk of PD.
We employed a geographic information system (GIS)-based model to estimate potential well-water contamination from agricultural pesticides among 368 cases and 341 population controls enrolled in the Parkinson's Environment and Genes Study (PEG). We separately examined 6 pesticides (diazinon, chlorpyrifos, propargite, paraquat, dimethoate, and methomyl) from among 26 chemicals selected for their potential to pollute groundwater or for their interest in PD, and because at least 10% of our population was exposed to them.
Cases were more likely to have consumed private well water and to have consumed it on average 4.3 years longer than controls (p = 0.02). High levels of possible well-water contamination with methomyl [odds ratio (OR) = 1.67; 95% confidence interval (CI), 1.00-2.78]), chlorpyrifos (OR = 1.87; 95% CI, 1.05-3.31), and propargite (OR = 1.92; 95% CI, 1.15-3.20) resulted in approximately 70-90% increases in relative risk of PD. Adjusting for ambient pesticide exposures only slightly attenuated these increases. Exposure to a higher number of water-soluble pesticides and organophosphate pesticides also increased the relative risk of PD.
Our study, the first to use agricultural pesticide application records, adds evidence that consuming well water presumably contaminated with pesticides may play a role in the etiology of PD.</description><subject>Adult</subject><subject>Aged</subject><subject>Agricultural chemicals</subject><subject>Chlorpyrifos</subject><subject>Consumption</subject><subject>Contamination</subject><subject>Exposure</subject><subject>Female</subject><subject>Geographic information systems</subject><subject>Health aspects</subject><subject>Herbicides</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Parkinson Disease - etiology</subject><subject>Parkinson's disease</subject><subject>Pesticides</subject><subject>Pesticides - toxicity</subject><subject>Risk</subject><subject>Risk factors</subject><subject>Rural Health</subject><subject>Water Pollutants, Chemical - toxicity</subject><subject>Water Supply - analysis</subject><subject>Well 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Perspect</addtitle><date>2009-12-01</date><risdate>2009</risdate><volume>117</volume><issue>12</issue><spage>1912</spage><epage>1918</epage><pages>1912-1918</pages><issn>0091-6765</issn><eissn>1552-9924</eissn><abstract>Investigators have hypothesized that consuming pesticide-contaminated well water plays a role in Parkinson's disease (PD), and several previous epidemiologic studies support this hypothesis.
We investigated whether consuming water from private wells located in areas with documented historical pesticide use was associated with an increased risk of PD.
We employed a geographic information system (GIS)-based model to estimate potential well-water contamination from agricultural pesticides among 368 cases and 341 population controls enrolled in the Parkinson's Environment and Genes Study (PEG). We separately examined 6 pesticides (diazinon, chlorpyrifos, propargite, paraquat, dimethoate, and methomyl) from among 26 chemicals selected for their potential to pollute groundwater or for their interest in PD, and because at least 10% of our population was exposed to them.
Cases were more likely to have consumed private well water and to have consumed it on average 4.3 years longer than controls (p = 0.02). High levels of possible well-water contamination with methomyl [odds ratio (OR) = 1.67; 95% confidence interval (CI), 1.00-2.78]), chlorpyrifos (OR = 1.87; 95% CI, 1.05-3.31), and propargite (OR = 1.92; 95% CI, 1.15-3.20) resulted in approximately 70-90% increases in relative risk of PD. Adjusting for ambient pesticide exposures only slightly attenuated these increases. Exposure to a higher number of water-soluble pesticides and organophosphate pesticides also increased the relative risk of PD.
Our study, the first to use agricultural pesticide application records, adds evidence that consuming well water presumably contaminated with pesticides may play a role in the etiology of PD.</abstract><cop>United States</cop><pub>National Institute of Environmental Health Sciences</pub><pmid>20049211</pmid><doi>10.1289/ehp.0900852</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| source | Jstor Complete Legacy; MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; PubMed Central Open Access |
| subjects | Adult Aged Agricultural chemicals Chlorpyrifos Consumption Contamination Exposure Female Geographic information systems Health aspects Herbicides Humans Male Middle Aged Parkinson Disease - etiology Parkinson's disease Pesticides Pesticides - toxicity Risk Risk factors Rural Health Water Pollutants, Chemical - toxicity Water Supply - analysis Well waters |
| title | Well-water consumption and Parkinson's disease in rural California |
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