The Caulerpa Pigment Caulerpin Inhibits HIF-1 Activation and Mitochondrial Respiration

The transcription factor hypoxia-inducible factor-1 (HIF-1) represents an important molecular target for anticancer drug discovery. In a T47D cell-based reporter assay, the Caulerpa spp. algal pigment caulerpin (1) inhibited hypoxia-induced as well as 1,10-phenanthroline-induced HIF-1 activation. Th...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2009-12, Vol.72 (12), p.2104-2109
Hauptverfasser:	Liu, Yang, Morgan, J. Brian, Coothankandaswamy, Veena, Liu, Rui, Jekabsons, Mika B, Mahdi, Fakhri, Nagle, Dale G, Zhou, Yu-Dong
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Caulerpa Caulerpa - chemistry Coloring Agents - chemistry Coloring Agents - pharmacology Electron Transport Complex I - antagonists & inhibitors Female General pharmacology Humans Hypoxia-Inducible Factor 1 - drug effects Indoles - chemistry Indoles - isolation & purification Indoles - pharmacology Medical sciences Mitochondria - drug effects Mitochondria - metabolism Molecular Structure Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Vascular Endothelial Growth Factor A - metabolism
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