Roles of Matrix Metalloproteinases in Flow-Induced Outward Vascular Remodeling

Sustained hemodynamic stresses, especially high blood flow, result in flow-induced outward vascular remodeling. Our previous study showed that macrophage depletion reduced flow-induced outward remodeling of the rat common carotid artery, indicating that macrophages are critical in flow-induced outwa...

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Veröffentlicht in:	Journal of cerebral blood flow and metabolism 2009-09, Vol.29 (9), p.1547-1558
Hauptverfasser:	Ota, Ryo, Kurihara, Chie, Tsou, Tsung-Ling, Young, William L, Yeghiazarians, Yerem, Chang, Mayland, Mobashery, Shahriar, Sakamoto, Atsuhiro, Hashimoto, Tomoki
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Blood Pressure - physiology Carotid Artery, Common - anatomy & histology Carotid Artery, Common - metabolism Cerebral circulation. Blood-brain barrier. Choroid plexus. Cerebrospinal fluid. Circumventricular organ. Meninges Doxycycline - metabolism Fundamental and applied biological sciences. Psychology Hemodynamics Male Matrix Metalloproteinase 12 - genetics Matrix Metalloproteinase 12 - metabolism Matrix Metalloproteinase 9 - genetics Matrix Metalloproteinase 9 - metabolism Matrix Metalloproteinase Inhibitors Medical sciences Mice Mice, Inbred C57BL Mice, Knockout Neovascularization, Physiologic - physiology Neurology Rats Regional Blood Flow - physiology Reproducibility of Results Vascular diseases and vascular malformations of the nervous system Vertebrates: nervous system and sense organs
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