Age-Related Vascular Pathology in Transgenic Mice Expressing Presenilin 1-Associated Familial Alzheimer's Disease Mutations

Mutations in the presenilin 1 (PS1) gene are the most commonly recognized cause of familial Alzheimer's disease (FAD). Besides senile plaques, neurofibrillary tangles, and neuronal loss, Alzheimer's disease (AD) is also accompanied by vascular pathology. Here we describe an age-related vas...

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Veröffentlicht in:	The American journal of pathology 2010, Vol.176 (1), p.353-368
Hauptverfasser:	Gama Sosa, Miguel A, Gasperi, Rita De, Rocher, Anne B, Wang, Athena Ching-Jung, Janssen, William G.M, Flores, Tony, Perez, Gissel M, Schmeidler, James, Dickstein, Dara L, Hof, Patrick R, Elder, Gregory A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult and adolescent clinical studies Aging - metabolism Aging - pathology Alzheimer Disease - genetics Animals Atrophy Basement Membrane - metabolism Biological and medical sciences Blood Vessels - abnormalities Blood Vessels - metabolism Blood Vessels - pathology Blood Vessels - ultrastructure Brain - blood supply Brain - metabolism Brain - pathology Brain - ultrastructure Chromosomes, Artificial, P1 Bacteriophage - genetics Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Dendrites - metabolism Dendrites - pathology Extracellular Matrix Proteins - metabolism Humans Investigative techniques, diagnostic techniques (general aspects) Medical sciences Mice Mice, Inbred C57BL Mice, Transgenic Microvessels - abnormalities Microvessels - metabolism Microvessels - pathology Microvessels - ultrastructure Mutant Proteins - metabolism Mutation - genetics Neurology Organic mental disorders. Neuropsychology Pathology Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Presenilin-1 - metabolism Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Regular Transgenes - genetics
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