Enoxaparin Improves the Course of Dextran Sodium Sulfate-Induced Colitis in Syndecan-1-Deficient Mice

Syndecan-1 (Sdc1) plays a major role in wound healing and modulates inflammatory responses. Sdc1 expression is reduced in lesions of patients with ulcerative colitis. The aim of this study was to investigate the role of Sdc1 in murine dextran sodium sulfate (DSS)-induced colitis. DSS colitis was ind...

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Veröffentlicht in:	The American journal of pathology 2010, Vol.176 (1), p.146-157
Hauptverfasser:	Floer, Martin, Götte, Martin, Wild, Martin K, Heidemann, Jan, Gassar, Ezeddin Salem, Domschke, Wolfram, Kiesel, Ludwig, Luegering, Andreas, Kucharzik, Torsten
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Caco-2 Cells Cell Adhesion - drug effects Cell Proliferation - drug effects Colitis - drug therapy Colitis - genetics Colitis - pathology Dextran Sulfate Enoxaparin - therapeutic use Fibroblast Growth Factor 2 - pharmacology Gene Expression Regulation - drug effects Gene Knockdown Techniques Humans Inflammation - genetics Intercellular Adhesion Molecule-1 - metabolism Intestines - drug effects Intestines - pathology Investigative techniques, diagnostic techniques (general aspects) Lymphoid Tissue - drug effects Lymphoid Tissue - metabolism MAP Kinase Signaling System - drug effects Medical sciences Mice Neutrophils - cytology Neutrophils - drug effects Pathology Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Regular RNA, Small Interfering - metabolism Syndecan-1 - deficiency Syndecan-1 - genetics Syndecan-1 - metabolism Wound Healing - drug effects
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