Risk Factors for Epithelial Ovarian Cancer by Histologic Subtype
Previous epidemiologic studies suggest that the major histologic subtypes of epithelial ovarian cancer may have different risk factor profiles; however, no known prospective study has systematically examined differences in risk by subtype. The authors used Cox proportional hazards regression, strati...
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| Veröffentlicht in: | American journal of epidemiology 2010-01, Vol.171 (1), p.45-53 |
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| creator | Gates, Margaret A. Rosner, Bernard A. Hecht, Jonathan L. Tworoger, Shelley S. |
| description | Previous epidemiologic studies suggest that the major histologic subtypes of epithelial ovarian cancer may have different risk factor profiles; however, no known prospective study has systematically examined differences in risk by subtype. The authors used Cox proportional hazards regression, stratified by histologic subtype and time period, to examine the association between ovarian cancer risk factors and incidence of serous invasive, endometrioid, and mucinous ovarian cancers in the US Nurses’ Health Study (1976–2006) and Nurses’ Health Study II (1989–2005). For each exposure, they calculated P-heterogeneity using a likelihood ratio test comparing models with separate estimates for the 3 subtypes versus a single estimate across subtypes. Analysis included 221,866 women and 721 cases with the histologies of interest (496 serous invasive, 139 endometrioid, 86 mucinous). In analyses of reproductive/hormonal exposures, the associations with age, duration of breastfeeding, age at natural menopause, and duration of estrogen use differed significantly by subtype (all P-heterogeneity ≤0.05). The associations with several nonreproductive exposures also appeared to vary by subtype, but only the association with smoking differed significantly (P-heterogeneity = 0.03). Results suggest that associations with several ovarian cancer risk factors vary by subtype, and these differences are consistent with known similarities between each major histologic subtype and its normal tissue counterpart. |
| doi_str_mv | 10.1093/aje/kwp314 |
| format | Article |
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The authors used Cox proportional hazards regression, stratified by histologic subtype and time period, to examine the association between ovarian cancer risk factors and incidence of serous invasive, endometrioid, and mucinous ovarian cancers in the US Nurses’ Health Study (1976–2006) and Nurses’ Health Study II (1989–2005). For each exposure, they calculated P-heterogeneity using a likelihood ratio test comparing models with separate estimates for the 3 subtypes versus a single estimate across subtypes. Analysis included 221,866 women and 721 cases with the histologies of interest (496 serous invasive, 139 endometrioid, 86 mucinous). In analyses of reproductive/hormonal exposures, the associations with age, duration of breastfeeding, age at natural menopause, and duration of estrogen use differed significantly by subtype (all P-heterogeneity ≤0.05). The associations with several nonreproductive exposures also appeared to vary by subtype, but only the association with smoking differed significantly (P-heterogeneity = 0.03). Results suggest that associations with several ovarian cancer risk factors vary by subtype, and these differences are consistent with known similarities between each major histologic subtype and its normal tissue counterpart.</description><identifier>ISSN: 0002-9262</identifier><identifier>EISSN: 1476-6256</identifier><identifier>DOI: 10.1093/aje/kwp314</identifier><identifier>PMID: 19910378</identifier><identifier>CODEN: AJEPAS</identifier><language>eng</language><publisher>Cary, NC: Oxford University Press</publisher><subject>adenocarcinoma ; Adenocarcinoma, Mucinous - epidemiology ; Adult ; Area Under Curve ; Biological and medical sciences ; Carcinogens ; carcinoma ; Carcinoma, Endometrioid - epidemiology ; Confidence Intervals ; cystadenocarcinoma ; Cystadenocarcinoma - epidemiology ; endometrioid ; Epidemiology ; Female ; Female genital diseases ; Gynecology. Andrology. Obstetrics ; Health Surveys ; histology ; Humans ; Medical sciences ; Middle Aged ; Models, Statistical ; mucinous ; Neoplasms, Glandular and Epithelial - epidemiology ; Neoplasms, Glandular and Epithelial - pathology ; Original Contributions ; Ovarian cancer ; ovarian neoplasms ; Ovarian Neoplasms - epidemiology ; Ovarian Neoplasms - pathology ; Proportional Hazards Models ; Regression Analysis ; Risk ; Risk Assessment ; Risk Factors ; serous ; Surveys and Questionnaires ; Tumors ; United States - epidemiology</subject><ispartof>American journal of epidemiology, 2010-01, Vol.171 (1), p.45-53</ispartof><rights>American Journal of Epidemiology © The Author 2009. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org. 2009</rights><rights>2015 INIST-CNRS</rights><rights>Copyright Oxford Publishing Limited(England) Jan 1, 2010</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c599t-3cfe28e1b33b3f3d01ff9b004c7e5b8020a3e67921dcd4e48818011723a9f1943</citedby><cites>FETCH-LOGICAL-c599t-3cfe28e1b33b3f3d01ff9b004c7e5b8020a3e67921dcd4e48818011723a9f1943</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,1578,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22323516$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19910378$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gates, Margaret A.</creatorcontrib><creatorcontrib>Rosner, Bernard A.</creatorcontrib><creatorcontrib>Hecht, Jonathan L.</creatorcontrib><creatorcontrib>Tworoger, Shelley S.</creatorcontrib><title>Risk Factors for Epithelial Ovarian Cancer by Histologic Subtype</title><title>American journal of epidemiology</title><addtitle>Am J Epidemiol</addtitle><description>Previous epidemiologic studies suggest that the major histologic subtypes of epithelial ovarian cancer may have different risk factor profiles; however, no known prospective study has systematically examined differences in risk by subtype. The authors used Cox proportional hazards regression, stratified by histologic subtype and time period, to examine the association between ovarian cancer risk factors and incidence of serous invasive, endometrioid, and mucinous ovarian cancers in the US Nurses’ Health Study (1976–2006) and Nurses’ Health Study II (1989–2005). For each exposure, they calculated P-heterogeneity using a likelihood ratio test comparing models with separate estimates for the 3 subtypes versus a single estimate across subtypes. Analysis included 221,866 women and 721 cases with the histologies of interest (496 serous invasive, 139 endometrioid, 86 mucinous). In analyses of reproductive/hormonal exposures, the associations with age, duration of breastfeeding, age at natural menopause, and duration of estrogen use differed significantly by subtype (all P-heterogeneity ≤0.05). The associations with several nonreproductive exposures also appeared to vary by subtype, but only the association with smoking differed significantly (P-heterogeneity = 0.03). Results suggest that associations with several ovarian cancer risk factors vary by subtype, and these differences are consistent with known similarities between each major histologic subtype and its normal tissue counterpart.</description><subject>adenocarcinoma</subject><subject>Adenocarcinoma, Mucinous - epidemiology</subject><subject>Adult</subject><subject>Area Under Curve</subject><subject>Biological and medical sciences</subject><subject>Carcinogens</subject><subject>carcinoma</subject><subject>Carcinoma, Endometrioid - epidemiology</subject><subject>Confidence Intervals</subject><subject>cystadenocarcinoma</subject><subject>Cystadenocarcinoma - epidemiology</subject><subject>endometrioid</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Female genital diseases</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Health Surveys</subject><subject>histology</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Models, Statistical</subject><subject>mucinous</subject><subject>Neoplasms, Glandular and Epithelial - epidemiology</subject><subject>Neoplasms, Glandular and Epithelial - pathology</subject><subject>Original Contributions</subject><subject>Ovarian cancer</subject><subject>ovarian neoplasms</subject><subject>Ovarian Neoplasms - epidemiology</subject><subject>Ovarian Neoplasms - pathology</subject><subject>Proportional Hazards Models</subject><subject>Regression Analysis</subject><subject>Risk</subject><subject>Risk Assessment</subject><subject>Risk Factors</subject><subject>serous</subject><subject>Surveys and Questionnaires</subject><subject>Tumors</subject><subject>United States - epidemiology</subject><issn>0002-9262</issn><issn>1476-6256</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90U9rHCEYBnApDc0m6aUfoAyF5lCYxldHHS-hZUmyhZRA_xFyEcfVxN3Zcaozaffb17DLpu0hJw_-eN5XH4ReAX4PWNITvbAny189heoZmkAleMkJ48_RBGNMSkk42UcHKS0wBpAMv0D7ICVgKuoJ-vDFp2Vxrs0QYipciMVZ74c723rdFlf3OnrdFVPdGRuLZl3MfBpCG269Kb6OzbDu7RHac7pN9uX2PETfz8--TWfl5dXFp-nHy9IwKYeSGmdJbaGhtKGOzjE4JxuMKyMsa2pMsKaWC0lgbuaVreoa6ryuIFRLB7Kih-h0k9uPzcrOje2GqFvVR7_Sca2C9urfm87fqdtwr4iQXNYPAcfbgBh-jjYNauWTsW2rOxvGpAgQwTmHDN_8BxdhjF1-nCKUSRBCsIzebZCJIaVo3W4TwOqhFZVbUZtWMn799-6PdFtDBm-3QCejWxfzh_u0c4TQPBn4owtj__TAcuNyXfb3Tuq4VFxQwdTs-kb9kNf45jNmitE_do6xDA</recordid><startdate>20100101</startdate><enddate>20100101</enddate><creator>Gates, Margaret A.</creator><creator>Rosner, Bernard A.</creator><creator>Hecht, Jonathan L.</creator><creator>Tworoger, Shelley S.</creator><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7T2</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7U1</scope><scope>5PM</scope></search><sort><creationdate>20100101</creationdate><title>Risk Factors for Epithelial Ovarian Cancer by Histologic Subtype</title><author>Gates, Margaret A. ; Rosner, Bernard A. ; Hecht, Jonathan L. ; Tworoger, Shelley S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c599t-3cfe28e1b33b3f3d01ff9b004c7e5b8020a3e67921dcd4e48818011723a9f1943</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>adenocarcinoma</topic><topic>Adenocarcinoma, Mucinous - epidemiology</topic><topic>Adult</topic><topic>Area Under Curve</topic><topic>Biological and medical sciences</topic><topic>Carcinogens</topic><topic>carcinoma</topic><topic>Carcinoma, Endometrioid - epidemiology</topic><topic>Confidence Intervals</topic><topic>cystadenocarcinoma</topic><topic>Cystadenocarcinoma - epidemiology</topic><topic>endometrioid</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Female genital diseases</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Health Surveys</topic><topic>histology</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Models, Statistical</topic><topic>mucinous</topic><topic>Neoplasms, Glandular and Epithelial - epidemiology</topic><topic>Neoplasms, Glandular and Epithelial - pathology</topic><topic>Original Contributions</topic><topic>Ovarian cancer</topic><topic>ovarian neoplasms</topic><topic>Ovarian Neoplasms - epidemiology</topic><topic>Ovarian Neoplasms - pathology</topic><topic>Proportional Hazards Models</topic><topic>Regression Analysis</topic><topic>Risk</topic><topic>Risk Assessment</topic><topic>Risk Factors</topic><topic>serous</topic><topic>Surveys and Questionnaires</topic><topic>Tumors</topic><topic>United States - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gates, Margaret A.</creatorcontrib><creatorcontrib>Rosner, Bernard A.</creatorcontrib><creatorcontrib>Hecht, Jonathan L.</creatorcontrib><creatorcontrib>Tworoger, Shelley S.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Risk Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>American journal of epidemiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gates, Margaret A.</au><au>Rosner, Bernard A.</au><au>Hecht, Jonathan L.</au><au>Tworoger, Shelley S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Risk Factors for Epithelial Ovarian Cancer by Histologic Subtype</atitle><jtitle>American journal of epidemiology</jtitle><addtitle>Am J Epidemiol</addtitle><date>2010-01-01</date><risdate>2010</risdate><volume>171</volume><issue>1</issue><spage>45</spage><epage>53</epage><pages>45-53</pages><issn>0002-9262</issn><eissn>1476-6256</eissn><coden>AJEPAS</coden><abstract>Previous epidemiologic studies suggest that the major histologic subtypes of epithelial ovarian cancer may have different risk factor profiles; however, no known prospective study has systematically examined differences in risk by subtype. The authors used Cox proportional hazards regression, stratified by histologic subtype and time period, to examine the association between ovarian cancer risk factors and incidence of serous invasive, endometrioid, and mucinous ovarian cancers in the US Nurses’ Health Study (1976–2006) and Nurses’ Health Study II (1989–2005). For each exposure, they calculated P-heterogeneity using a likelihood ratio test comparing models with separate estimates for the 3 subtypes versus a single estimate across subtypes. Analysis included 221,866 women and 721 cases with the histologies of interest (496 serous invasive, 139 endometrioid, 86 mucinous). In analyses of reproductive/hormonal exposures, the associations with age, duration of breastfeeding, age at natural menopause, and duration of estrogen use differed significantly by subtype (all P-heterogeneity ≤0.05). The associations with several nonreproductive exposures also appeared to vary by subtype, but only the association with smoking differed significantly (P-heterogeneity = 0.03). Results suggest that associations with several ovarian cancer risk factors vary by subtype, and these differences are consistent with known similarities between each major histologic subtype and its normal tissue counterpart.</abstract><cop>Cary, NC</cop><pub>Oxford University Press</pub><pmid>19910378</pmid><doi>10.1093/aje/kwp314</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | adenocarcinoma Adenocarcinoma, Mucinous - epidemiology Adult Area Under Curve Biological and medical sciences Carcinogens carcinoma Carcinoma, Endometrioid - epidemiology Confidence Intervals cystadenocarcinoma Cystadenocarcinoma - epidemiology endometrioid Epidemiology Female Female genital diseases Gynecology. Andrology. Obstetrics Health Surveys histology Humans Medical sciences Middle Aged Models, Statistical mucinous Neoplasms, Glandular and Epithelial - epidemiology Neoplasms, Glandular and Epithelial - pathology Original Contributions Ovarian cancer ovarian neoplasms Ovarian Neoplasms - epidemiology Ovarian Neoplasms - pathology Proportional Hazards Models Regression Analysis Risk Risk Assessment Risk Factors serous Surveys and Questionnaires Tumors United States - epidemiology |
| title | Risk Factors for Epithelial Ovarian Cancer by Histologic Subtype |
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