Structure-activity relationships of natural and non-natural amino acid-based amide and 2-oxoamide inhibitors of human phospholipase A2 enzymes

A variety of 2-oxoamides and related amides based on natural and non-natural amino acids were synthesized. Their activity on two human intracellular phospholipases (GIVA cPLA 2 and GVIA iPLA 2 ) and one human secretory phospholipase (GV sPLA 2 ) was evaluated. We show that an amide based on ( R )-γ-...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 2008-12, Vol.16 (24), p.10257-10269
Hauptverfasser:	ANTONOPOULOU, Georgia, BARBAYIANNI, Efrosini, MAGRIOTI, Victoria, COTTON, Naomi, STEPHENS, Daren, CONSTANTINOU-KOKOTOU, Violetta, DENNIS, Edward A, KOKOTOS, George
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Bones, joints and connective tissue. Antiinflammatory agents Medical sciences Pharmacology. Drug treatments
Online-Zugang:	Volltext
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