Retinotopic Mapping Requires Focal Adhesion Kinase-Mediated Regulation of Growth Cone Adhesion

Adhesion controls growth cone motility, yet the effects of axon guidance cues on adhesion site dynamics are poorly understood. Here we show that ephrin-A1 reduces retinal ganglion cell (RGC) axon outgrowth by stabilizing existing adhesions and inhibiting new adhesion assembly. Ephrin-A1 activates fo...

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Veröffentlicht in:	The Journal of neuroscience 2009-11, Vol.29 (44), p.13981-13991
Hauptverfasser:	Woo, Stephanie, Rowan, Daniel J, Gomez, Timothy M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Genetically Modified Cell Adhesion - physiology Cells, Cultured Chickens Enzyme Activation - physiology Focal Adhesion Protein-Tyrosine Kinases - physiology Growth Cones - enzymology Growth Cones - physiology Retina - enzymology Retina - physiology Xenopus laevis Zebrafish
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