In Utero Exposure to Di-(2-Ethylhexyl) Phthalate Decreases Mineralocorticoid Receptor Expression in the Adult Testis

In utero exposure to di-(2-ethylhexyl) phthalate (DEHP) has been shown to result in decreased androgen formation by fetal and adult rat testes. In the fetus, decreased androgen is accompanied by the reduced expression of steroidogenic enzymes. The mechanism by which in utero exposure results in redu...

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Veröffentlicht in:	Endocrinology (Philadelphia) 2009-12, Vol.150 (12), p.5575-5585
Hauptverfasser:	Martinez-Arguelles, D. B, Culty, M, Zirkin, B. R, Papadopoulos, V
Format:	Artikel
Sprache:	eng
Schlagworte:	Androgens Animals Bis(2-ethylhexyl) phthalate Cell activation CpG islands CpG Islands - genetics Deregulation Diethylhexyl Phthalate - toxicity Dioctyl phthalate DNA methylation DNA Methylation - drug effects Embryo, Mammalian - embryology Embryo, Mammalian - metabolism Exposure Female Fetuses Gene expression Gene Expression Regulation, Developmental - drug effects Gestational Age Hypotheses Immunoblotting Intermediate Filament Proteins - genetics Intermediate Filament Proteins - metabolism Intrauterine exposure Leydig cells Leydig Cells - drug effects Leydig Cells - metabolism Male Maternal Exposure Methylation Microscopy, Fluorescence Mineralocorticoid receptors Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Nestin Nuclear receptors Phthalate esters Phthalates Plasticizers - toxicity Pregnancy Prenatal Exposure Delayed Effects Rats Rats, Sprague-Dawley Receptors Receptors, Mineralocorticoid - genetics Receptors, Mineralocorticoid - metabolism Reverse Transcriptase Polymerase Chain Reaction Steroid hormone receptors Testes Testis - embryology Testis - growth & development Testis - metabolism Testosterone
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