Human cancers converge at the HIF-2α oncogenic axis

Cancer development is a multistep process, driven by a series of genetic and environmental alterations, that endows cells with a set of hallmark traits required for tumorigenesis. It is broadly accepted that growth signal autonomy, the first hallmark of malignancies, can be acquired through multiple...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2009-12, Vol.106 (50), p.21306-21311
Hauptverfasser:	Franovic, Aleksandra, Holterman, Chet E, Payette, Josianne, Lee, Stephen
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological Sciences Cancer Cell growth Cell lines HCT116 cells Human genetics Hypoxia Medical genetics Receptors Tumor cell line Tumors
Online-Zugang:	Volltext
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