FDG PET imaging of childhood sarcomas
Background Positron‐emission tomography (PET) imaging using [18F]fluorodeoxyglucose (FDG) is useful for detection, staging, and monitoring a variety of malignancies, including lymphoma, in adults, but its utility in sarcomas, especially soft tissue sarcomas (STS), in children and young adults is not...
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| Veröffentlicht in: | Pediatric blood & cancer 2010-02, Vol.54 (2), p.222-227 |
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| creator | Mody, Rajen J. Bui, Chuong Hutchinson, Raymond J. Yanik, Greg A. Castle, Valerie P. Frey, Kirk A. Shulkin, Barry L. |
| description | Background
Positron‐emission tomography (PET) imaging using [18F]fluorodeoxyglucose (FDG) is useful for detection, staging, and monitoring a variety of malignancies, including lymphoma, in adults, but its utility in sarcomas, especially soft tissue sarcomas (STS), in children and young adults is not clear.
Procedure
To evaluate the potential utility of FDG PET in the care of STS in children and young adults, we analyzed 46 PET scans in 25 patients acquired over 12 years. Scans were interpreted by two imaging physicians blinded to findings from other imaging studies and clinical information. Results were compared with computed tomography and magnetic resonance imaging, biopsy results, where available, and clinical follow‐up of at least 12 months.
Results
For a total of 46 scans in 25 patients, there were 25 true‐positive scans, 3 false‐positive scans, 12 true‐negative scans, and 6 false‐negative scans. The sensitivity of the PET scan was 86%, specificity was 80%, positive predictive value was 89%, and negative predictive value was 67%.
Conclusion
FDG PET may be a useful imaging modality in the management of children and young adults with STS, although prospective studies are needed to establish its true utility. Pediatr Blood Cancer 2010;54:222–227. © 2009 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/pbc.22307 |
| format | Article |
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Positron‐emission tomography (PET) imaging using [18F]fluorodeoxyglucose (FDG) is useful for detection, staging, and monitoring a variety of malignancies, including lymphoma, in adults, but its utility in sarcomas, especially soft tissue sarcomas (STS), in children and young adults is not clear.
Procedure
To evaluate the potential utility of FDG PET in the care of STS in children and young adults, we analyzed 46 PET scans in 25 patients acquired over 12 years. Scans were interpreted by two imaging physicians blinded to findings from other imaging studies and clinical information. Results were compared with computed tomography and magnetic resonance imaging, biopsy results, where available, and clinical follow‐up of at least 12 months.
Results
For a total of 46 scans in 25 patients, there were 25 true‐positive scans, 3 false‐positive scans, 12 true‐negative scans, and 6 false‐negative scans. The sensitivity of the PET scan was 86%, specificity was 80%, positive predictive value was 89%, and negative predictive value was 67%.
Conclusion
FDG PET may be a useful imaging modality in the management of children and young adults with STS, although prospective studies are needed to establish its true utility. Pediatr Blood Cancer 2010;54:222–227. © 2009 Wiley‐Liss, Inc.</description><identifier>ISSN: 1545-5009</identifier><identifier>EISSN: 1545-5017</identifier><identifier>DOI: 10.1002/pbc.22307</identifier><identifier>PMID: 19890901</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adolescent ; Biopsy ; Child ; Child, Preschool ; Ewing ; FDG ; Female ; fluorodeoxyglucose ; Fluorodeoxyglucose F18 ; Humans ; Magnetic Resonance Imaging ; Male ; Neoplasm Staging ; Neuroectodermal Tumors, Primitive - diagnostic imaging ; Neuroectodermal Tumors, Primitive - pathology ; pediatric ; PET ; Positron-Emission Tomography ; Radiopharmaceuticals ; Retrospective Studies ; rhabdomyosarcoma ; Rhabdomyosarcoma - diagnostic imaging ; Rhabdomyosarcoma - pathology ; Sarcoma, Ewing - diagnostic imaging ; Sarcoma, Ewing - pathology ; Sensitivity and Specificity ; Single-Blind Method ; Tomography, X-Ray Computed ; Young Adult</subject><ispartof>Pediatric blood & cancer, 2010-02, Vol.54 (2), p.222-227</ispartof><rights>Copyright © 2009 Wiley‐Liss, Inc.</rights><rights>(c) 2009 Wiley-Liss, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4527-c1700d53a039ed14f3a5c44e298a103c910e8a1875cf563e6ded964832d2968e3</citedby><cites>FETCH-LOGICAL-c4527-c1700d53a039ed14f3a5c44e298a103c910e8a1875cf563e6ded964832d2968e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fpbc.22307$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fpbc.22307$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,776,780,881,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19890901$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mody, Rajen J.</creatorcontrib><creatorcontrib>Bui, Chuong</creatorcontrib><creatorcontrib>Hutchinson, Raymond J.</creatorcontrib><creatorcontrib>Yanik, Greg A.</creatorcontrib><creatorcontrib>Castle, Valerie P.</creatorcontrib><creatorcontrib>Frey, Kirk A.</creatorcontrib><creatorcontrib>Shulkin, Barry L.</creatorcontrib><title>FDG PET imaging of childhood sarcomas</title><title>Pediatric blood & cancer</title><addtitle>Pediatr. Blood Cancer</addtitle><description>Background
Positron‐emission tomography (PET) imaging using [18F]fluorodeoxyglucose (FDG) is useful for detection, staging, and monitoring a variety of malignancies, including lymphoma, in adults, but its utility in sarcomas, especially soft tissue sarcomas (STS), in children and young adults is not clear.
Procedure
To evaluate the potential utility of FDG PET in the care of STS in children and young adults, we analyzed 46 PET scans in 25 patients acquired over 12 years. Scans were interpreted by two imaging physicians blinded to findings from other imaging studies and clinical information. Results were compared with computed tomography and magnetic resonance imaging, biopsy results, where available, and clinical follow‐up of at least 12 months.
Results
For a total of 46 scans in 25 patients, there were 25 true‐positive scans, 3 false‐positive scans, 12 true‐negative scans, and 6 false‐negative scans. The sensitivity of the PET scan was 86%, specificity was 80%, positive predictive value was 89%, and negative predictive value was 67%.
Conclusion
FDG PET may be a useful imaging modality in the management of children and young adults with STS, although prospective studies are needed to establish its true utility. Pediatr Blood Cancer 2010;54:222–227. © 2009 Wiley‐Liss, Inc.</description><subject>Adolescent</subject><subject>Biopsy</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Ewing</subject><subject>FDG</subject><subject>Female</subject><subject>fluorodeoxyglucose</subject><subject>Fluorodeoxyglucose F18</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Neoplasm Staging</subject><subject>Neuroectodermal Tumors, Primitive - diagnostic imaging</subject><subject>Neuroectodermal Tumors, Primitive - pathology</subject><subject>pediatric</subject><subject>PET</subject><subject>Positron-Emission Tomography</subject><subject>Radiopharmaceuticals</subject><subject>Retrospective Studies</subject><subject>rhabdomyosarcoma</subject><subject>Rhabdomyosarcoma - diagnostic imaging</subject><subject>Rhabdomyosarcoma - pathology</subject><subject>Sarcoma, Ewing - diagnostic imaging</subject><subject>Sarcoma, Ewing - pathology</subject><subject>Sensitivity and Specificity</subject><subject>Single-Blind Method</subject><subject>Tomography, X-Ray Computed</subject><subject>Young Adult</subject><issn>1545-5009</issn><issn>1545-5017</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kE1PwkAQhjdGI4oe_AOmF2M8FPaz272YKEI1QUWD0dtm2W6h2naxCyr_3mIR9eBpJplnnpm8ABwg2EIQ4vZ0pFsYE8g3wA5ilPkMIr657qFogF3nnis0gCzcBg0kQgEFRDvgqHcReYPu0EtzNU6LsWcTT0_SLJ5YG3tOldrmyu2BrURlzuyvahM89LrDzqXfv42uOmd9X1OGua8RhzBmREEiTIxoQhTTlBosQoUg0QJBU3UhZzphATFBbGIR0JDgGIsgNKQJTmvvdD7KTaxNMStVJqdl9V25kFal8u-kSCdybN8k5oIKJirB8UpQ2te5cTOZp06bLFOFsXMnOSGEYkqX5ElN6tI6V5pkfQVBuUxVVqnKr1Qr9vD3Wz_kKsYKaNfAe5qZxf8mOTjvfCv9eiN1M_Ox3lDliww44Uw-3kTyiUT8LryH8pp8AjM7jjM</recordid><startdate>201002</startdate><enddate>201002</enddate><creator>Mody, Rajen J.</creator><creator>Bui, Chuong</creator><creator>Hutchinson, Raymond J.</creator><creator>Yanik, Greg A.</creator><creator>Castle, Valerie P.</creator><creator>Frey, Kirk A.</creator><creator>Shulkin, Barry L.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201002</creationdate><title>FDG PET imaging of childhood sarcomas</title><author>Mody, Rajen J. ; Bui, Chuong ; Hutchinson, Raymond J. ; Yanik, Greg A. ; Castle, Valerie P. ; Frey, Kirk A. ; Shulkin, Barry L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4527-c1700d53a039ed14f3a5c44e298a103c910e8a1875cf563e6ded964832d2968e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adolescent</topic><topic>Biopsy</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Ewing</topic><topic>FDG</topic><topic>Female</topic><topic>fluorodeoxyglucose</topic><topic>Fluorodeoxyglucose F18</topic><topic>Humans</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Neoplasm Staging</topic><topic>Neuroectodermal Tumors, Primitive - diagnostic imaging</topic><topic>Neuroectodermal Tumors, Primitive - pathology</topic><topic>pediatric</topic><topic>PET</topic><topic>Positron-Emission Tomography</topic><topic>Radiopharmaceuticals</topic><topic>Retrospective Studies</topic><topic>rhabdomyosarcoma</topic><topic>Rhabdomyosarcoma - diagnostic imaging</topic><topic>Rhabdomyosarcoma - pathology</topic><topic>Sarcoma, Ewing - diagnostic imaging</topic><topic>Sarcoma, Ewing - pathology</topic><topic>Sensitivity and Specificity</topic><topic>Single-Blind Method</topic><topic>Tomography, X-Ray Computed</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mody, Rajen J.</creatorcontrib><creatorcontrib>Bui, Chuong</creatorcontrib><creatorcontrib>Hutchinson, Raymond J.</creatorcontrib><creatorcontrib>Yanik, Greg A.</creatorcontrib><creatorcontrib>Castle, Valerie P.</creatorcontrib><creatorcontrib>Frey, Kirk A.</creatorcontrib><creatorcontrib>Shulkin, Barry L.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Pediatric blood & cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mody, Rajen J.</au><au>Bui, Chuong</au><au>Hutchinson, Raymond J.</au><au>Yanik, Greg A.</au><au>Castle, Valerie P.</au><au>Frey, Kirk A.</au><au>Shulkin, Barry L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>FDG PET imaging of childhood sarcomas</atitle><jtitle>Pediatric blood & cancer</jtitle><addtitle>Pediatr. Blood Cancer</addtitle><date>2010-02</date><risdate>2010</risdate><volume>54</volume><issue>2</issue><spage>222</spage><epage>227</epage><pages>222-227</pages><issn>1545-5009</issn><eissn>1545-5017</eissn><abstract>Background
Positron‐emission tomography (PET) imaging using [18F]fluorodeoxyglucose (FDG) is useful for detection, staging, and monitoring a variety of malignancies, including lymphoma, in adults, but its utility in sarcomas, especially soft tissue sarcomas (STS), in children and young adults is not clear.
Procedure
To evaluate the potential utility of FDG PET in the care of STS in children and young adults, we analyzed 46 PET scans in 25 patients acquired over 12 years. Scans were interpreted by two imaging physicians blinded to findings from other imaging studies and clinical information. Results were compared with computed tomography and magnetic resonance imaging, biopsy results, where available, and clinical follow‐up of at least 12 months.
Results
For a total of 46 scans in 25 patients, there were 25 true‐positive scans, 3 false‐positive scans, 12 true‐negative scans, and 6 false‐negative scans. The sensitivity of the PET scan was 86%, specificity was 80%, positive predictive value was 89%, and negative predictive value was 67%.
Conclusion
FDG PET may be a useful imaging modality in the management of children and young adults with STS, although prospective studies are needed to establish its true utility. Pediatr Blood Cancer 2010;54:222–227. © 2009 Wiley‐Liss, Inc.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>19890901</pmid><doi>10.1002/pbc.22307</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Biopsy Child Child, Preschool Ewing FDG Female fluorodeoxyglucose Fluorodeoxyglucose F18 Humans Magnetic Resonance Imaging Male Neoplasm Staging Neuroectodermal Tumors, Primitive - diagnostic imaging Neuroectodermal Tumors, Primitive - pathology pediatric PET Positron-Emission Tomography Radiopharmaceuticals Retrospective Studies rhabdomyosarcoma Rhabdomyosarcoma - diagnostic imaging Rhabdomyosarcoma - pathology Sarcoma, Ewing - diagnostic imaging Sarcoma, Ewing - pathology Sensitivity and Specificity Single-Blind Method Tomography, X-Ray Computed Young Adult |
| title | FDG PET imaging of childhood sarcomas |
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