Withaferin A targets heat shock protein 90 in pancreatic cancer cells

The purpose of this study is to investigate the efficacy and the mechanism of Hsp90 inhibition of Withaferin A (WA), a steroidal lactone occurring in Withania somnifera, in pancreatic cancer in vitro and in vivo. Withaferin A exhibited potent antiproliferative activity against pancreatic cancer cell...

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Veröffentlicht in:	Biochemical pharmacology 2010-02, Vol.79 (4), p.542-551
Hauptverfasser:	Yu, Yanke, Hamza, Adel, Zhang, Tao, Gu, Mancang, Zou, Peng, Newman, Bryan, Li, Yanyan, Gunatilaka, A.A. Leslie, Zhan, Chang-Guo, Sun, Duxin
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cdc37 Cell Cycle Proteins - antagonists & inhibitors Cell Cycle Proteins - metabolism Cell Line, Tumor Chaperonins - antagonists & inhibitors Chaperonins - metabolism Client protein Drug Delivery Systems - methods Ergosterol - analogs & derivatives Ergosterol - metabolism Ergosterol - pharmacology Female Gastroenterology. Liver. Pancreas. Abdomen Hsp90 HSP90 Heat-Shock Proteins - metabolism Humans Liver. Biliary tract. Portal circulation. Exocrine pancreas Medical sciences Mice Mice, Nude Pancreatic cancer Pancreatic Neoplasms - drug therapy Pancreatic Neoplasms - metabolism Pharmacology. Drug treatments Reactive cysteine Tumors Withaferin A Withanolides Xenograft Model Antitumor Assays - methods
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