The 3′–5′ proofreading exonuclease of archaeal family-B DNA polymerase hinders the copying of template strand deaminated bases

Archaeal family B polymerases bind tightly to the deaminated bases uracil and hypoxanthine in single-stranded DNA, stalling replication on encountering these pro-mutagenic deoxynucleosides four steps ahead of the primer–template junction. When uracil is specifically bound, the polymerase–DNA complex...

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Veröffentlicht in:	Nucleic acids research 2009-12, Vol.37 (22), p.7603-7611
Hauptverfasser:	Russell, Henry J., Richardson, Tomas T., Emptage, Kieran, Connolly, Bernard A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Archaeal Proteins - chemistry Archaeal Proteins - metabolism Deamination DNA Primers DNA-Directed DNA Polymerase - chemistry DNA-Directed DNA Polymerase - metabolism Exodeoxyribonucleases - chemistry Exodeoxyribonucleases - metabolism Hypoxanthine - chemistry Hypoxanthine - metabolism Nucleic Acid Enzymes Pyrococcus furiosus Pyrococcus furiosus - enzymology Templates, Genetic Uracil - chemistry Uracil - metabolism
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