High Rates and Substrate Selectivities in Water by Polyvinylimidazoles as Transaminase Enzyme Mimics with Hydrophobically Bound Pyridoxamine Derivatives as Coenzyme Mimics

Free-radical polymers of 4-vinylimidazole and copolymers with 1-dodecyl-4-vinylimidazole were used as enzyme mimics to transaminate pyruvic acid to alanine, phenylpyruvic acid to phenylalanine, and indole-3-pyruvic acid to tryptophan in water at pH 7.5 and 20 °C using pyridoxamines carrying hydropho...

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Veröffentlicht in:	Journal of the American Chemical Society 2009-11, Vol.131 (43), p.15604-15605
Hauptverfasser:	Skouta, Rachid, Wei, Sujun, Breslow, Ronald
Format:	Artikel
Sprache:	eng
Schlagworte:	Imidazoles - chemistry Molecular Mimicry Polyvinyls - chemistry Pyridoxamine - metabolism Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Spectrophotometry, Ultraviolet Substrate Specificity Transaminases - metabolism Water - chemistry
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