Evidence that multiple genetic variants of MC4R play a functional role in the regulation of energy expenditure and appetite in Hispanic children

BACKGROUND: Melanocortin-4-receptor (MC4R) haploinsufficiency is the most common form of monogenic obesity; however, the frequency of MC4R variants and their functional effects in general populations remain uncertain. OBJECTIVE: The aim was to identify and characterize the effects of MC4R variants i...

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Veröffentlicht in:	The American journal of clinical nutrition 2010-01, Vol.91 (1), p.191-199
Hauptverfasser:	Cole, Shelley A, Butte, Nancy F, Voruganti, V. Saroja, Cai, Guowen, Haack, Karin, Kent, Jack W. Jr, Blangero, John, Comuzzie, Anthony G, McPherson, John D, Gibbs, Richard A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult appetite Appetite - genetics Bayesian analysis Bayesian theory Biological and medical sciences Body Mass Index Body Size Child children Children & youth Chromosomes, Human, Pair 18 Effects energy expenditure Energy Intake Energy Metabolism - genetics Exercise Exons Family Feeding. Feeding behavior Fundamental and applied biological sciences. Psychology Gene-nutrient interactions genetic techniques and protocols Genetic Variation Genotype Genotype & phenotype Hispanic or Latino - genetics Hispanic people Hispanics human genetics Humans Life Style Linkage Disequilibrium - genetics melanocortin-4-receptor MicroRNAs - genetics molecular sequence data nucleotide sequences Obesity Obesity - genetics Original Research Communications Overweight - epidemiology Overweight - genetics Parents phenotype Polymorphism Polymorphism, Single Nucleotide Receptor, Melanocortin, Type 4 - genetics receptors single nucleotide polymorphism Vertebrates: anatomy and physiology, studies on body, several organs or systems weight control
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