Group II metabotropic glutamate receptors and schizophrenia
Schizophrenia is one of the most common mental illnesses, with hereditary and environmental factors important for its etiology. All antipsychotics have in common a high affinity for monoaminergic receptors. Whereas hallucinations and delusions usually respond to typical (haloperidol-like) and atypic...
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| Veröffentlicht in: | Cellular and molecular life sciences : CMLS 2009-12, Vol.66 (23), p.3777-3785 |
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| creator | Moreno, José L Sealfon, Stuart C González-Maeso, Javier |
| description | Schizophrenia is one of the most common mental illnesses, with hereditary and environmental factors important for its etiology. All antipsychotics have in common a high affinity for monoaminergic receptors. Whereas hallucinations and delusions usually respond to typical (haloperidol-like) and atypical (clozapine-like) monoaminergic antipsychotics, their efficacy in improving negative symptoms and cognitive deficits remains inadequate. In addition, devastating side effects are a common characteristic of monoaminergic antipsychotics. Recent biochemical, preclinical and clinical findings support group II metabotropic glutamate receptors (mGluR2 and mGluR3) as a new approach to treat schizophrenia. This paper reviews the status of general knowledge of mGluR2 and mGluR3 in the psychopharmacology, genetics and neuropathology of schizophrenia |
| doi_str_mv | 10.1007/s00018-009-0130-3 |
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All antipsychotics have in common a high affinity for monoaminergic receptors. Whereas hallucinations and delusions usually respond to typical (haloperidol-like) and atypical (clozapine-like) monoaminergic antipsychotics, their efficacy in improving negative symptoms and cognitive deficits remains inadequate. In addition, devastating side effects are a common characteristic of monoaminergic antipsychotics. Recent biochemical, preclinical and clinical findings support group II metabotropic glutamate receptors (mGluR2 and mGluR3) as a new approach to treat schizophrenia. This paper reviews the status of general knowledge of mGluR2 and mGluR3 in the psychopharmacology, genetics and neuropathology of schizophrenia</description><identifier>ISSN: 1420-682X</identifier><identifier>EISSN: 1420-9071</identifier><identifier>DOI: 10.1007/s00018-009-0130-3</identifier><identifier>PMID: 19707855</identifier><language>eng</language><publisher>Basel: Basel : SP Birkhäuser Verlag Basel</publisher><subject>Animals ; Antipsychotic Agents - pharmacokinetics ; Antipsychotics ; Biochemistry ; Biomedical and Life Sciences ; Biomedicine ; Cell Biology ; Environmental factors ; Genetics ; Humans ; Life Sciences ; Mental disorders ; Mice ; Models, Biological ; Molecular biology ; Neurosciences ; Pharmacology ; Receptors, Metabotropic Glutamate - genetics ; Receptors, Metabotropic Glutamate - metabolism ; Receptors, Metabotropic Glutamate - physiology ; Review ; Schizophrenia ; Schizophrenia - metabolism</subject><ispartof>Cellular and molecular life sciences : CMLS, 2009-12, Vol.66 (23), p.3777-3785</ispartof><rights>Birkhäuser Verlag, Basel/Switzerland 2009</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c590t-bd5336010437d61af0cf667c195e6283ce5348aa133c0dd546b664a3cb4f74303</citedby><cites>FETCH-LOGICAL-c590t-bd5336010437d61af0cf667c195e6283ce5348aa133c0dd546b664a3cb4f74303</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2792875/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2792875/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,724,777,781,882,27905,27906,41469,42538,51300,53772,53774</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19707855$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Moreno, José L</creatorcontrib><creatorcontrib>Sealfon, Stuart C</creatorcontrib><creatorcontrib>González-Maeso, Javier</creatorcontrib><title>Group II metabotropic glutamate receptors and schizophrenia</title><title>Cellular and molecular life sciences : CMLS</title><addtitle>Cell. Mol. Life Sci</addtitle><addtitle>Cell Mol Life Sci</addtitle><description>Schizophrenia is one of the most common mental illnesses, with hereditary and environmental factors important for its etiology. All antipsychotics have in common a high affinity for monoaminergic receptors. Whereas hallucinations and delusions usually respond to typical (haloperidol-like) and atypical (clozapine-like) monoaminergic antipsychotics, their efficacy in improving negative symptoms and cognitive deficits remains inadequate. In addition, devastating side effects are a common characteristic of monoaminergic antipsychotics. Recent biochemical, preclinical and clinical findings support group II metabotropic glutamate receptors (mGluR2 and mGluR3) as a new approach to treat schizophrenia. This paper reviews the status of general knowledge of mGluR2 and mGluR3 in the psychopharmacology, genetics and neuropathology of schizophrenia</description><subject>Animals</subject><subject>Antipsychotic Agents - pharmacokinetics</subject><subject>Antipsychotics</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cell Biology</subject><subject>Environmental factors</subject><subject>Genetics</subject><subject>Humans</subject><subject>Life Sciences</subject><subject>Mental disorders</subject><subject>Mice</subject><subject>Models, Biological</subject><subject>Molecular biology</subject><subject>Neurosciences</subject><subject>Pharmacology</subject><subject>Receptors, Metabotropic Glutamate - genetics</subject><subject>Receptors, Metabotropic Glutamate - metabolism</subject><subject>Receptors, Metabotropic Glutamate - 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| subjects | Animals Antipsychotic Agents - pharmacokinetics Antipsychotics Biochemistry Biomedical and Life Sciences Biomedicine Cell Biology Environmental factors Genetics Humans Life Sciences Mental disorders Mice Models, Biological Molecular biology Neurosciences Pharmacology Receptors, Metabotropic Glutamate - genetics Receptors, Metabotropic Glutamate - metabolism Receptors, Metabotropic Glutamate - physiology Review Schizophrenia Schizophrenia - metabolism |
| title | Group II metabotropic glutamate receptors and schizophrenia |
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